Publications 2012-2002

2012

Chodorge, M., Züger, S., Stirnimann, C., Briand, C., Jermutus, L., Grütter, MG. & Minter, RR.
A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Diff. [Epub ahead of print]

2011

Bourquin, F., Capitani, G. & Grütter, MG.
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. Protein Sci. 20, 1492-1508 (2011).

Brandstätter L., Sokolova L., Eicher T., Seeger MA., Briand C., Cha HJ., Cernescu M., Bohnert J., Kern WV., Brutschy B., Pos KM.
Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS Biochim Biophys Acta. 1808, 2189-96 (2011).

Devi, VS, & Mittl. PR.
Monitoring the disulfide bond formation of a cysteine-rich repeat proteine from Helicobacter pylori in the periplasm of escherichia coli. Curr Microbiol. 62, 903-907 (2011).

Flütsch, A., Schröder, T., Grütter MG. & Patzke, GR.
HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorg. Med. Chem. Lett. 21, 1162-1166 (2011).

Ganesan, R., Jelakovic, S., Mittl, PR., Caflisch, A. & Grütter, MG.
In silico identification and crystal structure validation of procaspase-3 inhibitors without a P1 aspartic acid moiety. Acta Crystallogr SectF Struct Biol Cryst Commun. 67, 842-850 (2011).

Huwiler, A., Bourquin, F., Kotelevets, N., Pastukhov, O., Capitani, G., Grütter, MG. & Zangemeister-Wittke, U.
A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLoS One. 6(8): e22436 (2011).

Monroe, N., Sennhauser, G., Seeger, M., Briand, C. & Grütter, MG.
Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface. J. Struct. Biol. 174, 269-281 (2011).

Pertel, T.,Hausmann, S., Morger, D., Züger, S., Guerra, J., Lascano, J., Reinhard, C., Santoni, FA., Uchil, PD., Chatel, L., Bisiaux, A., Albert, ML., Strambio-De-Castillia, C., Mothes, W., Pizzato, M., Grutter, MG. & Luban, J.
TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 472, 361-365 (2011).

Roschitzki, B.,Schauer, S. & Mittl, PR.
Recognition of host proteins by Helicobacter cysteine-rich proteine C. Curr Microbiol. 63, 239-249 (2011).

Schärer, MA., Eliot, AC., Grütter, MG. & Capitani, G.
Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy . FEBS Lett. 585, 111-114 (2011).

2010

Bourquin, F., Riezman, H., Capitani, G. & Grütter, MG.
Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure 18, 1054-1065 (2010).

Keller, N., Grütter, MG. & Zerbe, O.
Studies of the molecular mechanism of caspase-8 activation by solution NMR. Cell Death Differ. 17, 710-718 (2010).

Kindermann, M., Roschitzki-Voser, H., Caglic, D., Repnik, U., Miniejew, C., Mittl, PR., Kosec, G., Grütter, MG., Turk, B.& Wendt, KU.
Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 17, 999-1007 (2010).

Kramer, MA., Wetzel, SK:, Plückthun, A., Mittl, PR. & Grütter, MG.
Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned c-capping module. J Mol Biol. 404, 381-391 (2010).

Melkko S, Mannocci L, Dumelin CE, Villa A, Sommavilla R, Zhang Y, Grütter MG, Keller N, Jermutus L, Jackson RH, Scheuermann J & Neri D.
Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library. Chem Med Chem. 5, 584-590 (2010).

Pham,QT., Bouchard, A., Grütter, MG. & Berthoux, L.
Generation of human TRIM5alpha mutants with high HIV-1 restriction acitivity. Gene Ther. 17, 859-871 (2010).

Schärer, MA., Grütter, MG. & Capitani, G.
CRK: an evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts. Proteins 78, 2707-2713 (2010).

Schoep,TD., Fulurija, A., Good, F., Lu, W., Hirnbeck, RP., Schwan, C., Choi, SS., Berg, DE., Mittl, PR., Benghezal, M. & Marshall, BJ.
Surface properties of Helicobacter pylori urease complex are essential for persistence. PLoS One. 5 e15042 (2010).

2009

Baumgartner R., Meder G., Briand C., Decock A., D'arcy A., Hassiepen U., Morse R. & Renatus M.
The crystal structure of caspase-6, a selective effector of axonal degeneration. Biochem J. 423, 429-39 (2009).

Dumrese C., Slomianka L., Ziegler U., Choi S.S., Kalia A., Fulurija A., Lu W., Berg D.E., Benghezal M., Marshall B. & Mittl P.R. The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype. FEBS Lett. 583, 1637-43 (2009).

Gut H., Dominici P., Pilati S., Astegno A., Petoukhov M.V., Svergun D.I., Grütter M.G. & Capitani G.
A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J Mol Biol. 392 ,334-51 (2009).

Keller N., Grütter M.G. & Zerbe O.
Studies of the molecular mechanism of caspase-8 activation by solution NMR. Cell Death Differ. , 1-9 (2009).

Keller N., Mares J., Zerbe O. & Grütter M.G.
Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation. Structure. 17, 438-48 (2009).

Neagu M.R., Ziegler P., Pertel T., Strambio-De-Castillia C., Grütter C., Martinetti G., Mazzucchelli L., Grütter M.G., Manz M.G. & Luban J.
Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest. 119 3035-47 (2009).

Schulz B.L., Stirnimann C.U., Grimshaw J.P., Brozzo M.S., Fritsch F., Mohorko E., Capitani G., Glockshuber R., Grütter M.G. & Aebi M.
Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc Natl Acad Sci U S A. 106, 11061-6 (2009).

Sebastian S., Grütter C., Strambio de Castillia C., Pertel T., Olivari S., Grütter M.G. & Luban J.
An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding. J Virol. 83, 3365-73 (2009).

Sennhauser G., Bukowska M.A., Briand C. & Grütter M.G.
Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa. J Mol Biol. 389, 134-45 (2009).

Weinert C., Grütter C., Roschitzki-Voser H., Mittl P.R. & Grütter M.G.
The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever. J Mol Biol. 394226-36 (2009).

2008

Eidam O., Dworkowski F.S., Glockshuber R., Grütter M.G. & Capitani G.
Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD. FEBS Lett. 582, 651-5 (2008).

Frey D., Huber T., Plückthun A. & Grütter M.G.
Structure of the recombinant antibody Fab fragment f3p4. Acta Crystallogr. D Biol. Crystallogr. 64, 636-43 (2008).

Grimshaw J.P., Stirnimann C.U., Brozzo M.S., Malojcic G., Grütter M.G., Capitani G. & Glockshuber R.
DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli. J Mol. Biol. 380, 667-80 (2008).

Grütter C, Wilkinson T, Turner R, Podichetty S, Finch D, McCourt M, Loning S, Jermutus L, Grütter MG.
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions. Proc Natl Acad Sci U S A. 105, 20251-6 (2008).

Hartmann C., Chami M., Zachariae U., de Groot B.L., Engel A. & Grütter M.G.
Vacuolar Protein Sorting: Two Different Functional States of the AAA-ATPase Vps4p. J. Mol. Biol. 377, 352-63 (2008).

Merz T., Svava K.W., Firbank S., Plückthun A., Grütter, M.G. & Mittl P.R.E.
Stabilizing ionic interactions in a full-consensus ankyrin repeat protein. J. Mol. Biol. 376, 232-40 (2008).

Puorger C., Eidam O., Capitani G., Erilov D., Grütter M.G., and Glockshuber R.
Infinite Kinetic Stability against Dissociation of Supramolecular Protein Complexes through Donor Strand Complementation. Structure. 16, 631-642 (2008).

Mukhopadhyay D., Howell, KS., Riezmann, H. & Capitani, G.
Sphinganine-1-phosphate lyase: Identifying key residues for function in vivo and in vitro. J Biol Chem. 283, 20159-20169 (2008).

Narzi, D., Siu, SW., Stirnimann, CU., Grimshaw, JP., Glockshuber, R., Capitani, G. & Böckmann, RA.
Evidence for proton shuffling in a thioredoxin-like protein during catalysis. J Mol Biol. 382, 978-986 (2008).

Sennhauser, G. & Grütter M.G.
Chaperone-assisted crystallography with DARPins. Structure. 16, 1443-1453 (2008).

Vacca, RA., Giannattasio, S., Capitani, G., Marra, E. & Christen, P.
Molecular evolution of B6 enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme. BMC Biochem. 9, 17 (2008).

2007

Göschke R., Stutz S., Rasetti V., Cohen N.C., Rahuel J., Rigollier P., Baum H.P., Forgiarini P., Schnell C.R., Wagner T., Grütter M.G., Fuhrer W., Schilling W., Cumin F., Wood J.M. & Maibaum J.
Novel 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin. J. Med. Chem. 50, 4818-31 (2007).

Maibaum J., Stutz S., Göschke R., Rigollier P., Yamaguchi Y., Cumin F., Rahuel J., Baum H.P., Cohen N.C., Schnell C.R., Fuhrer W., Grütter M.G., Schilling W & Wood J.M.
Structural Modification of the P2' Position of 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8- phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets. J. Med. Chem. 50, 4832-44 (2007).

Mittl P.R. & Schneider-Brachert W. Sel1-like repeat proteins in signal transduction. Cell Signal. 19, 20-31 (2007).

Papin S., Cuenin S., Agostini L., Martinon F., Werner S., Beer H.D., Grütter C., Grütter M.G. & Tschopp J. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 8, 1457-66 (2007).

Schweizer A., Roschitzki-Voser H., Amstutz P., Briand C., Gulotti-Georgieva M., Prenosil E., Binz HK., Capitani G., Baici A., Plückthun A. & Grütter M.G. Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism. Structure 15, 625-36 (2007).
*Salvesen GS, Riedl SJ. Caspase inhibition, specifically. Structure 15, 513-4 (2007).

Sennhauser G., Amstutz P., Briand C., Storchenegger O. & Grütter M.G. Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors. PLoS Biol. 5, e7 (2007).

2006

Binz H.K., Kohl A., Plückthun A & Grütter M.G. Crystal structure of a consensus-designed ankyrin repeat protein: implications for stability. Proteins 65, 280-84 (2006).

Capitani G., Eidam O. & Grütter, M.G. Evidence for a novel domain of bacterial outer membrane ushers. Proteins 65, 816-23 (2006).

Capitani G., Eidam O., Glockshuber R. & Grütter M.G. Structural and functional insights into the assembly of type 1 pili from Escherichia coli. Microbes Infect. 8, 2284-90 (2006).

Ekici O.D., Li Z.Z., Campbell A.J., James K.E., Asgian J.L., Mikolajczyk J., Salvesen G.S., Ganesan R., Jelakovic S., Grütter M.G. & Powers J.C. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J. Med. Chem. 49, 5728-49 (2006).

Fasan R., Dias R.L., Moehle K., Zerbe O., Obrecht D., Mittl P.R., Grütter M.G. & Robinson J.A. Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction. Chembiochem. 7, 515-26 (2006).

Frey D., Braun O., Briand C., Vasak M. & Grütter M.G. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure 14, 901-11 (2006).

Ganesan R., Jelakovic S., Campbell A.J., Li Z.Z., Asgian J.L., Powers J.C. & Grütter M.G. Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors. Biochemistry 45, 9059-67 (2006).

Ganesan R., Mittl P.R., Jelakovic S. & Grütter M.G. Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol. 359, 1378-88 (2006).

Grütter, C., Briand, C., Capitani, G., Mittl, P.R., Papin, S., Tschopp, J. & Grütter, M.G. Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett. 580, 99-106 (2006).

Gut H., Pennacchietti E., John R.A., Bossa F., Capitani G., De Biase D & Grütter M.G. Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J. 25, 2643-51 (2006).

Mittl P.R. & Grütter M.G. Opportunities for structure-based design of protease-directed drugs. Curr Opin Struct Biol.16, 769-75 (2006).

Stirnimann C.U., Grütter M.G., Glockshuber R. & Capitani G. nDsbD: a redox interaction hub in the Escherichia coli periplasm. Cell Mol Life Sci. 63, 1642-48 (2006).

Stirnimann C.U.,Rozhkova A., Grauschopf U., Bockmann R.A., Glockshuber R., Capitani G. & Grütter M.G. High-resolution Structures of Escherichia coli cDsbD in Different Redox States: A Combined Crystallographic, Biochemical and Computational Study. J Mol Biol. 358, 829-45 (2006).

Tao M., Turk K., Diez J., Grütter M.G., Fritz G. & Steuber J. Crystallization of the NADH-oxidizing domain of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Acta Crystallogr. F 62, 110-2 (2006).

Yu H., Kohl A., Binz H.K., Plückthun A., Grütter M.G. & van Gunsteren W.F. Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins. Proteins 65, 285-95 (2006).

2005

Amstutz, P., Binz, H.K., Parizek, P., Stumpp, M.T., Kohl, A., Grütter, M.G., Forrer, P. & Plückthun, A. Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins. J Biol Chem. 280, 24715-24722 (2005).

Capitani, G., De Biase, D., Gut, H., Ahmed, S. & Grütter, M.G. Structural model of human GAD65: Prediction and interpretation of biochemical and immunogenic features. Proteins 59, 7-14 (2005).

Capitani, G., Tschopp, M., Eliot, A.C., F., K.J. & Grütter, M.G. Structure of ACC synthase inactivated by the mechanism-based inhibitor l-vinylglycine. FEBS Lett. 579, 2458-2462 (2005).

Deriu D., Gassmann M., Firbank S., Ristig D., Lampert C., Mosbacher J., Froestl W., Kaupmann K., Bettler B. & Grütter M.G. Determination of the minimal functional ligand-binding domain of the GABAB1b receptor. Biochem J. 386, 423-31 (2005).

Kohl, A., Amstutz, P., Parizek, P., Binz, H.K., Briand, C., Capitani, G., Forrer, P., Pluckthun, A. & Grütter, M.G. Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein. Structure 13, 1131-1141 (2005).
*Wright G.D. Allostery trumps antibiotic resistance. Structure 13, 1089-90 (2005).

Nishiyama, M., Horst, R., Eidam, O., Herrmann, T., Ignatov, O., Vetsch, M., Bettendorff, P., Jelesarov, I., Grütter, M.G., Wuthrich, K., Glockshuber, R. & Capitani, G. Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD. Embo J. 24, 2075-2086 (2005).

Stirnimann, C.U., Rozhkova, A., Grauschopf, U., Grütter, M.G., Glockshuber, R. & Capitani, G. Structural basis and kinetics of DsbD-dependent cytochrome c maturation. Structure 13, 985-993 (2005).

2004

Binz, H.K., Amstutz, P., Kohl, A., Stumpp, M.T., Briand, C., Forrer, P., Grütter, M.G. & Plückthun, A. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat. Biotechnol. 22, 575-82 (2004).

Capitani, G. & Schürmann, P. On the quaternary assembly of spinach chloroplast thioredoxin m. Photosynth. Res. 79, 281-85 (2004).

Kohl, A., Grütter, M.G. Fire and death: the pyrin domain joins the death-domain superfamily. C R Biol. 327, 1077-1086 (2004).

Lüthy, L., Grütter, M.G. & Mittl, P.R. The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins. J. Mol. Biol. 340, 829-41 (2004).

Rozhkova, A., Stirnimann, C.U., Frei, P., Grauschopf, U., Brunisholz, R., Grütter, M.G., Capitani, G. & Glockshuber, R. Structural basis and kinetics of inter- and intramolecular disulfide exchange in the redox catalyst DsbD. Embo J. 23, 1709-19 (2004).

2003

Capitani, G., Tramonti, A., Bossa, F., Grütter, M.G. & De Biase, D. The critical structural role of a highly conserved histidine residue in group II amino acid decarboxylases. FEBS Lett. 554, 41-4 (2003).

Capitani, G., De Biase, D., Aurizi, C., Gut, H., Bossa, F. & Grütter, M.G. Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase. Embo J. 22, 4027-37 (2003).

Capitani, G., Eliot, A.C., Gut, H., Khomutov, R.M., Kirsch, J.F. & Grütter, M.G. Structure of 1-aminocyclopropane-1-carboxylate synthase in complex with an amino-oxy analogue of the substrate: implications for substrate binding. Biochim. Biophys. Acta 543, 11-5 (2003).

Ciatto, C., Capitani, G., Tissot, A.C., Pecorari, F., Plückthun, A. & Grütter, M.G. Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db. FEBS Lett. 543, 11-5 (2003).

Cowan-Jacob, S.W., Kaufmann, M., Anselmo, A.N., Stark, W. & Grütter, M.G. Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr. D 59, 2218-27 (2003).

Deriu, D., Briand, C., Mistiniene, E., Naktinis, V. & Grütter, M.G. Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Acta Crystallogr. D 59, 1676-8 (2003).

Donepudi, M., Mac Sweeney, A., Briand, C. & Grütter, M.G. Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell 11, 543-9 (2003).

Hiller, S., Kohl, A., Fiorito, F., Herrmann, T., Wider, G., Tschopp, J., Grütter, M.G. & Wüthrich, K. NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure 11, 1199-205 (2003).
*Eliezer D. Folding pyrin into the family. Structure 11, 1190-1 (2003).

Kohl, A., Binz, H.K., Forrer, P., Stumpp, M.T., Plückthun, A. & Grütter, M.G. Designed to be stable: crystal structure of a consensus ankyrin repeat protein. P. Natl. Acad. Sci. USA 100, 1700-5 (2003).

Schweizer, A., Briand, C. & Grütter, M.G. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J. Biol. Chem. 278, 42441-7 (2003).

Wood, J.M., Maibaum, J., Rahuel, J., Grütter, M.G., Cohen, N.C., Rasetti, V., Ruger, H., Goschke, R., Stutz, S., Fuhrer, W., Schilling, W., Rigollier, P., Yamaguchi, Y., Cumin, F., Baum, H.P., Schnell, C.R., Herold, P., Mah, R., Jensen, C., O'Brien, E., Stanton, A. & Bedigian, M.P. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem. Biophy. Res. Co. 308, 698-705 (2003).

2002

Capitani, G., McCarthy, D.L., Gut, H., Grütter, M.G. & Kirsch, J.F. Apple 1-aminocyclopropane-1-carboxylate synthase in complex with the inhibitor L-aminoethoxyvinylglycine. Evidence for a ketimine intermediate. J. Biol. Chem. 277, 49735-42 (2002).

Daubenberger, C.A., Nickel, B., Ciatto, C., Grütter, M.G., Poltl-Frank, F., Rossi, L., Siegler, U., Robinson, J., Kashala, O., Patarroyo, M.E. & Pluschke, G. Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of Plasmodium falciparum merozoite surface protein 1 displaying dimorphic amino acid polymorphism are highly constrained. Eur. J. Immunol. 32, 3667-77 (2002).

Donepudi, M. & Grütter, M.G. Structure and zymogen activation of caspases. Biophys. Chem. 102, 145-53 (2002).

Fluckiger, S., Mittl, P.R., Scapozza, L., Fijten, H., Folkers, G., Grütter, M.G., Blaser, K. & Crameri, R. Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2 A resolution. J. Immunol. 168, 1267-72 (2002).

Fritz, G., Mittl, P.R., Vasak, M., Grütter, M.G. & Heizmann, C.W. The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution. J. Biol. Chem. 277, 33092-8 (2002).

Kaufmann, M., Bozic, D., Briand, C., Bodmer, J.L., Zerbe, O., Kohl, A., Tschopp, J. & Grütter, M.G. Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett. 527, 250-4 (2002).

Kaufmann, M., Lindner, P., Honegger, A., Blank, K., Tschopp, M., Capitani, G., Pluckthun, A. & Grütter, M.G. Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen. J. Mol. Biol. 318, 135-47 (2002).

Lüthy, L., Grütter, M.G. & Mittl, P.R. The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein. J. Biol. Chem. 277, 10187-93 (2002).

Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D.W., Briand, C. & Grütter, M.G. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277, 45162-71 (2002).

Mittl, P.R., Fritz, G., Sargent, D.F., Richmond, T.J., Heizmann, C.W. & Grütter, M.G. Metal-free MIRAS phasing: structure of apo-S100A3. Acta Crystallogr. D 58, 1255-61 (2002).