Structural aspects of Metallothioneins
useful literature references

Books
Out of the four International Metallothionein Meetings organized up to now
three proceedings have been published. They belong to the library of each MT
scientist. These are:
Metallothionein, Experientia Suppl. 34 (1979) ed. by
Jeremias H.R. Kägi & Monica Nordberg, Birkhäuser Verlag
Metallothionein II, Experientia Suppl. 52 (1987) ed. by
Jeremias H.R. Kägi & Yutaka Kojima, Birkhäuser Verlag
Metallothionein III; Biological roles and medical implications
(1993) ed. by K.T. Suzuki, N. Imura & M. Kimura, Birkhäuser Verlag
Metallothionein IV (1999) C. Klaassen (ed.), Birkhäuser Verlag Basel
(contains the extended abstracts presented at the Fourth
International Metallothionein Meeting, Kansas City (MO), 17th.-20th. September
1997)
Additional rich sources of information are to be found in:
Metallothionein; Synthesis, structure and properties of
metallothioneins, phytochelatins and metal-thiolate complexes (1991) ed.
by Martin J. Stillman, C. Frank Shaw III & Kazuo T. Suzuki, VHC Publishers,
Inc.
Metallobiochemistry Part B: Metallothionein and related molecules
(1991) Methods in enzymology 205, ed. by James F. Riordan & Bert L.
Vallee, Academic Press, Inc.
Reviews and articles
Here is a list of reviews and articles tracing structural
aspects of metallothioneins.
W. Braun, M. Vasak. A.H. Robbins, C.D. Stout, G. Wagner,J.H.R. Kägi
and K. Wüthrich (1992) Comparison of the NMR solution structure and the
x-ray crystal structure of rat metallothionein-2, Proceedings of the
National Academy of Sciences of the United States of America 89(21)
, 10124-10128. Medline
J.H.R. Kägi and A. Schäffer (1988) Biochemistry of
metallothionein, Biochemistry 27, 8509-8515. Medline
S.S Narula, M. Brouwer, Y. Hua and I.M. Armitage (1995) Three-dimensional
solution structure of Callinectes sapidus metallothionein-1 determined by
homonuclear and heteronuclear magnetic resonance spectroscopy, Biochemistry
34(2),620-31. Medline
J.D. Otvos, D.H. Petering and C.F. Shaw III (1989) Comments in
Inorganic Chemistry 9, 1-
M.J. Stillman (1995) Coordination Chemistry Reviews 144,
461-511
M. Vasak and J.H.R. Kägi (1983) Spectroscopic properties of
metallothionein, in Metal Ions in Biological Systems, Vol. 15,
Helmut Siegel ed., Marcel Dekker, Inc, New York, 213-273
M. Vasak and J.H.R. Kägi (1994) Metallothioneins, in
Encyclopedia of Inorganic Chemistry, Vol. 4, R. Bruce King ed.,
John Wiley & Sons, 2229-2241
M. Vasak and R. Bogumil (1997) Diversity of cluster structures in
mammalian metallothionein: Interplay between metal ions and polypeptide chain,
in Cytotoxic, mutagenic and carcinogenic potential of heavy metals related
to human environment, NATO ASI series II, ed. by D.D. Hadjiladis, Kluwer
Academic Publishers, 195-215
D.R. Winge, C.T. Dameron and G.N. George (1994) The metallothionein
structural motif in gene expression, Advances in Inorganic Biochemistry
10, 1-48. Medline
Metallothionein homepage/MT links
Pierre-Alain Binz
Updated the 28th Oct. 1999