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Biochemisches Institut

Calendar of Events


As of September 1st, 2020 the UZH corona safety concept mandates that a mask must be worn in all publicly accessible indoor areas. When delivering protein samples to PCC, you must wear a face mask from the moment you enter an UZH building.

Also adhere to the following federal and cantonal corona safety key rules:
> Keep a minimum of 1.5m distance to other people at all times.
> Stay at home when feeling ill or have returned from a high-risk area.

Thank you for your cooperation. Stay healthy!

New screen:

The Small Molecule Anion screen developed by Prof. Dr. Bernhard Spingler (UZH) is now available as GS086 .

Crystal Screen 1+2 Cryo GS084
Hampton Research screen detail: HR2-122 + HR2-121

The Ammonium sulfate screen GS002 has been newly designed and is now available as GS085.

What’s new:

What's New in ROCK MAKER 3.17? Protein Crystallization Software Update ROCK MAKER® 3.17


Department of Biochemistry
University of Zurich
Winterthurerstr. 190
CH-8057 Zurich
Office: Y44 J 30/34

Beat Blattmann
Tel.: +41 44 635 6557
Christoph Blattmann
Tel.: +41 44 635 5548

Protein Crystallization Center - PCC

The Protein Crystallization Center – PCC@UZH – supports the structural biology research community by setting up and monitor high-throughput protein crystallization experiments at the nano-liter scale. PCC@UZH offers as a service a wide range of crystallization techniques for soluble and membrane proteins. The crystallization service is open to all academic research groups and to private industry.

Proteins are the largest group of non-aqueous components in living cells. Almost every chemical reaction in a living cell requires a specific enzyme; this class of protein is also the most diverse. Knowing the 3-D structure of enzymes is vital to understand cellular processes. From the techniques used for the structure determination of macromolecules X-ray crystallography is the most productive method to date.
Crystals of a protein are prerequisite for structure determination by X-ray crystallography. Since the crystallization of bio molecules is a poorly understood process, high-throughput crystallization screening methods have to be used to find a successful condition for a new protein. Using vapor diffusion as the most common crystallization technique a combination of condition variables has to be determined for each protein. Condition variables are e.g. the protein concentration, the temperature, pH, and the concentration of a wide range of precipitation agents in combination with various salts. High throughput screening in combination with miniaturizing the crystallization experiment to 100nl is a practical solution for finding a suitable crystallization condition out of a large number of tests by using only a small amount of purified protein.

For more information how to get your protein crystallized go to:

Crystallization Tutorial:Terese Bergfors

CSIRO.au - User Guide:Collaborative Crystallisation Centre (C3)

Crystallization Protocol:Oxford Protein Production Facility - UK

Hampton Research: Crystal Growth 101 Literature

Molecular Dimensions: Technical Tips