Publikationen 2022

nach Erscheinungsdatum in PubMed: 

Strubel, A., Münick, P., Chaikuad, A., Dreier, B., Schaefer, J., Gebel, J., Osterburg, C., Tuppi, M., Schäfer, B., Knapp, S., Plückthun, A. & Dötsch, V. Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death Differ [Epub ahead of print] (2022). PMID: 35717504.


Ilie, IM., Bacci, M., Vitalis, A. & Caflisch, A. Antibody binding modulates the dynamics of the membrane bound prion protein. Biophys J [Epub ahead of print] (2022). PMID: 35672948.

Michel, E., Cucuzza, S., Mittl, PRE., Zerbe, O. & Plückthun, A. Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry [Epub ahead of print] (2022). PMID: 35657362.


Andrés Vargas-Rosales, P. & Caflisch, A. Domino effect in allosteric signaling of peptide binding. J Mol Biol [Epub ahead of print] (2022). PMID: 35640719.

Tatli, M., Moraïs, S., Tovar-Herrera, OE., Bomble, YJ., Bayer, EA., Medalia, O. & Mizrahi, I. Nanoscale resolution of microbial fiber degradation in action. Elife [Epub ahead of print] (2022). PMID: 35638899.

Lam, AKM., Rutz, S. & Dutzler, R. Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC. Nat Commun 13, 2798 (2022). PMID: 35589730.

Guimaraes Koch, SS., Thorpe, R., Kawasaki, N., Lefranc, MP., Malan, S., Martin, ACR., Mignot, G., Plückthun, A., Rizzi, M., Shubat, S., Weisser, K. & Balocco, R. International nonproprietary names for monoclonal antibodies: an evolving nomenclature system. MAbs 14, 2075078 (2022). PMID: 35584276.

Dultz, E., Wojtynek, M., Medalia, O. & Onischenko, E. The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth. Cells 11, (2022). PMID: 35563762.


Sawicka, M. & Dutzler, R. Regulators of cell volume: The structural and functional properties of anion channels of the LRRC8 family. Curr Opin Struct Biol [Epub ahead of print] (2022). PMID: 35504105.

Lone, MA., Bourquin, F. & Hornemann, T. Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases. Adv Exp Med Biol 1372, 47-56 (2022). PMID: 35503173.

Wang, L., Moreira, EA., Kempf, G., Miyake, Y., Oliveira Esteves, BI., Fahmi, A., Schaefer, JV., Dreier, B., Yamauchi, Y., Alves, MP., Plückthun, A. & Matthias, P. Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Rep 39, 110736 (2022). PMID: 35476995.

Fay, R., Törő, I., Schinke, AL., Simic, B., Schaefer, JV., Dreier, B., Plückthun, A. & Holland, JP. 89Zr-Radiolabeling of Designed Ankyrin Repeat Proteins for PET. Mol Pharm [Epub ahead of print] (2022). PMID: 35434995.

Stelzl, LS., Pietrek, LM., Holla, A., Oroz, J., Sikora, M., Köfinger, J., Schuler, B., Zweckstetter, M. & Hummer, G. Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure. JACS Au 2, 673-686 (2022). PMID: 35373198.

García-Viñuales, S., Ilie, IM., Santoro, AM., Romanucci, V., Zarrelli, A., Di Fabio, G., Caflisch, A. & Milardi, D. Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions. Biochim Biophys Acta Proteins Proteom 1870, 140772 (2022). PMID: 35307557.  

Wu, H., Shen, Y., Sivagurunathan, S., Weber, MS., Adam, SA., Shin, JH., Fredberg, JJ., Medalia, O., Goldman, R. & Weitz, DA. Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex. Proc Natl Acad Sci U S A 119, e2115217119 (2022). PMID: 35235449.

Qi, C., Lavriha, P., Mehta, V., Khanppnavar, B., Mohammed, I., Li, Y., Lazaratos, M., Schaefer, JV., Dreier, B., Plückthun, A., Bondar, AN., Dessauer, CW. & Korkhov, VM. Structural basis of adenylyl cyclase 9 activation. Nat Commun 13, 1045 (2022). PMID: 35210418.

Vahabikashi, A., Adam, SA., Medalia, O. & Goldman, RD. Nuclear lamins: Structure and function in mechanobiology. APL Bioeng 6, 011503 (2022). PMID: 35146235.

Schöppe, J., Ehrenmann, J., Waltenspühl, Y. & Plückthun, A. Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP. Nat Protoc [Epub ahead of print] (2022). PMID: 35140409.

de Leeuw, R., Kronenberg-Tenga, R., Eibauer, M. & Medalia, O. C. elegans lamin in the absence of helix 1A. Nucleus 13, 49-57 (2022). PMID: 35130129.

Salutari, I. & Caflisch, A. Dynamics of the Histone Acetyltransferase Lysine-Rich Loop in the Catalytic Core of the CREB-Binding Protein. J Chem Inf Model [Epub ahead of print] (2022). PMID: 35119862.

Gisdon, FJ., Kynast, JP., Ayyildiz, M., Hine, AV., Plückthun, A. & Höcker, B. Modular peptide binders - development of a predictive technology as alternative for reagent antibodies. Biol Chem [Epub ahead of print] (2022). PMID: 35089661.

Martinsen, JH., Saar, D., Fernandes, CB., Schuler, B., Bugge, K. & Kragelund, BB. Structure, Dynamics and Stability of the Globular Domain of Human Linker Histone H1.0 and the Role of Positive Charges. Protein Sci [Epub ahead of print] (2022). PMID: 35066947.

Deluigi, M., Morstein, L., Schuster, M., Klenk, C., Merklinger, L., Cridge, RR., de Zhang, LA., Klipp, A., Vacca, S., Vaid, TM., Mittl, PRE., Egloff, P., Eberle, SA., Zerbe, O., Chalmers, DK., Scott, DJ. & Plückthun, A. 1B-adrenergic receptor reveals molecular determinants of selective ligand recognition. Nat Commun 13, 382 (2022). PMID: 35046410.

Matsuda, S., Schaefer, JV., Mii, Y., Hori, Y., Bieli, D., Taira, M., Plückthun, A. & Affolter, M. Author Correction: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nat Commun 13, 389 (2022). PMID: 35031605

Ramanadane, K., Straub, MS., Dutzler, R. & Manatschal, C. Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. Elife 11, (2022). PMID: 35001872.

Heidarsson, PO., Mercadante, D., Sottini, A., Nettels, D., Borgia, MB., Borgia, A., Kilic, S., Fierz, B., Best, RB. & Schuler, B. Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein. Nat Chem 14, 224-231 (2022). PMID: 34992286.

Nüesch, MF., Ivanović, MT., Claude, JB., Nettels, D., Best, RB., Wenger, J. & Schuler, B. Single-molecule Detection of Ultrafast Biomolecular Dynamics with Nanophotonics. J Am Chem Soc 144, 52-56 (2022). PMID: 34970909.

Nass, KJ., Ilie, IM., Saller, MJ., Driessen, AJM., Caflisch, A., Kammerer, RA. & Li, X. The role of the N-terminal amphipathic helix (N-AH) in bacterial YidC: Insights from functional studies, the crystal structure and molecular dynamics simulations. Biochim Biophys Acta Biomembr  1864, 183825 (2022). PMID: 34871574.

Zosel, F., Holla, A. & Schuler, B. Labeling of Proteins for Single-Molecule Fluorescence Spectroscopy. Methods Mol Biol 2376, 207-233 (2022). PMID: 34845612.

Schilling, J., Jost, C., Ilie, IM., Schnabl, J., Buechi, O., Eapen, RS., Truffer, R., Caflisch, A. & Forrer, P. Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs. J Biol Chem 298(1), 101403 (2022). PMID: 34793836.