Structure Gallery 2013

The following structures have been solved using our high throughput crystallization services:

Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction.
Phongtongpasuk S, Paulus S, Schnabl J, Sigel RK, Spingler B, Hannon MJ, Freisinger E.
Angew Chem Int Ed Engl. 2013 Oct 25;52(44):11513-6. doi: 10.1002/anie.201305079. Epub 2013 Aug 23

PDB ID:4JIY

 

Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.
Renciuk D, Blacque O, Vorlickova M, Spingler B.
Nucleic Acids Res. 2013 Nov;41(21):9891-900. doi: 10.1093/nar/gkt738. Epub 2013 Aug 20.
PMID: 23963698

PDB ID:4HLI

 

Precision is essential for efficient catalysis in an evolved Kemp eliminase.
Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D.
Nature. 2013 Nov 21;503(7476):418-21.
PDB ID:4BS0

 

Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2
Jost C, Schilling J, Tamaskovic R, Schwill M, Honegger A, Plückthun A.
Structure. 2013 Nov 5;21(11):1979-91.
PDB ID:4HRN,4HRM,4HRL

 

Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity.
Seeger MA, Zbinden R, Flütsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grütter MG.
Protein Sci. 2013 Sep;22(9):1239-57
PDB ID:4JB8

 

Structural basis for regulation of human glucokinase by glucokinase regulatory protein.
Beck T, Miller BG.
Biochemistry. 2013 Sep 10;52(36):6232-9.
PDB ID: 4LC9

 

The structure of Bradyrhizobium japonicum transcription factor FixK2 unveils sites of DNA binding and oxidation.
Bonnet M, Kurz M, Mesa S, Briand C, Hennecke H, Grütter MG.
J Biol Chem. 2013 May 17;288(20):14238-46.
PDB ID: 4I2O

 

Crystal structure of the complex between prokaryotic ubiquitin-like protein and its ligase PafA.
Barandun J, Delley CL, Ban N, Weber-Ban E.
J Am Chem Soc. 2013 May 8;135(18):6794-7.
PDB ID: 4BJR

 

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A.
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E869-77.
PDB ID:4ATZ