Structure Gallery 2016

The following structures have been solved using our high throughput crystallization services:


DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography.
Batyuk A, Wu Y, Honegger A, Heberling MM, Plückthun A.
J Mol Biol. 2016 Apr 24;428(8):1574-88. doi: 10.1016/j.jmb.2016.03.002. Epub 2016 Mar 11.

The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations.
Schaffer MF, Peng G, Spingler B, Schnabl J, Wang M, Olieric V, and Sigel RKO.
Int J Mol Sci. 2016 Jul; 17(7): 988.

Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity.
Hansen S, Tremmel D, Madhurantakam C, Reichen C, Mittl PR, Plückthun A.
J Am Chem Soc. 2016 Mar 16;138(10):3526-32. doi: 10.1021/jacs.6b00099. Epub 2016 Mar 2.

Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.
Schütz M, Batyuk A, Klenk C, Kummer L, de Picciotto S, Gülbakan B, Wu Y1, Newby GA, Zosel F, Schöppe J, Sedlák E, Mittl PRE, Zenobi R, Wittrup KD, Plückthun A.
J Mol Biol. 2016 Mar 27;428(6):1272-1289. doi: 10.1016/j.jmb.2016.01.017. Epub 2016 Jan 23.

Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
Reichen C, Hansen S, Forzani C, Honegger A, Fleishman SJ, Zhou T, Parmeggiani F, Ernst P, Madhurantakam C, Ewald C, Mittl PRE, Zerbe O, Baker D, Caflisch A, Plückthun A.
J Mol Biol. 2016 Nov 6;428(22):4467-4489. doi: 10.1016/j.jmb.2016.09.012. Epub 2016 Sep 21.

Structural Analysis of the Bacterial Proteasome Activator Bpa in Complex with the 20S Proteasome.
Bolten M, Delley CL, Leibundgut M, Boehringer D, Ban N, Weber-Ban E.
Structure. 2016 Dec 6;24(12):2138-2151. doi: 10.1016/j.str.2016.10.008. Epub 2016 Nov 10.

A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme.
Green AP, Hayashi T, Mittl PR, Hilvert D.
J Am Chem Soc. 2016 Sep 7;138(35):11344-52. doi: 10.1021/jacs.6b07029. Epub 2016 Aug 26.

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6.
Niewoehner O, Jinek M.
RNA. 2016 Mar;22(3):318-29. doi: 10.1261/rna.054098.115. Epub 2016 Jan 13.