Structure Gallery 2017

The following structures have been solved using our high throughput crystallization services:

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LAB, Laferriere F, Maniecka Z, Plückthun A, Mittl P, Paganetti P, Allain FHT, Polymenidou M.
Nat Commun. 2017 Jun 29;8(1):45. doi: 10.1038/s41467-017-00062-0.

Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.
Ehrnstorfer IA, Manatschal C, Arnold FM, Laederach J & Dutzler R.
Nat Commun. 2017 Jan 6; 8: 14033. doi: 10.1038/ncomms14033.

Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity.
Hansen S, Stüber JC, Ernst P, Koch A, Bojar D, Batyuk A, Plückthun A.
Sci Rep. 2017 Nov 24;7(1):16292. doi: 10.1038/s41598-017-15711-z.

Structures of designed armadillo repeat proteins binding to peptides fused to globular domains.
Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Plückthun A.
Protein Sci. 2017 Oct;26(10):1942-1952. doi: 10.1002/pro.3229. Epub 2017 Jul 25.

Rigidly connected multispecific artificial binders with adjustable geometries.
Wu Y, Batyuk A, Honegger A, Brandl F, Mittl PRE & Plückthun A. 
Sci Rep. 2017, Sep 11; 7: 11217.  doi:10.1038/s41598-017-11472-x

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
Bärlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA & Hilbi H.
Nat Commun. 2017 Nov 16; 8(1): 1543. doi: 10.1038/s41467-017-01512-5

Production, Purification and Crystallization of a Prokaryotic SLC26 Homolog for Structural Studies.
Chang Y, Shaik FR, Neldner Y, Geertsma ER.
Bio-protocol. 2017 Feb 5; 7(3): e2116. doi: 10.21769/BioProtoc.2116.

Depupylase Dop Requires Inorganic Phosphate in the Active Site for Catalysis.
Bolten M, Vahlensieck C, Lipp C, Leibundgut M, Ban N, Weber-Ban E.
J Biol Chem. 2017 Mar 10;292(10):4044-4053. doi: 10.1074/jbc.M116.755645. Epub 2017 Jan 24.

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.
Obexer R, Godina A, Garrabou X, Mittl PR, Baker D, Griffiths AD, Hilvert D.
Nat Chem. 2017 Jan;9(1):50-56. doi: 10.1038/nchem.2596. Epub 2016 Aug 29.