Structure Gallery 2019

The following structures have been solved using our high throughput crystallization services:

Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template
Flavio M. Gall, Deborah Hohl, David Frasson, Tobias Wermelinger, Priv.-Doz. Dr. Peer R. E. Mittl, Prof. Dr. Martin Sievers, Prof. Dr. Rainer Riedl
Angew.Chem. Int.Ed. 2019, 58,4051 –4055

The extracellular gate shapes the energy profile of an ABC exporter
Cedric A.J. Hutter, M. Hadi Timachi, Lea M. Hürlimann, Iwan Zimmermann, Pascal Egloff, Hendrik Göddeke, Svetlana Kucher, Saša Štefanić, Mikko Karttunen, Lars V. Schäfer, Enrica Bordignon & Markus A. Seeger
NATURE COMMUNICATIONS | (2019) 10:2260 | |

Structural analysis of biological targets by host:guest crystal lattice engineering
Patrick Ernst, Andreas Plückthun & Peer R. E. Mittl
Scientific RepoRtS | (2019) 9:15199 |

Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
Andreas U. Müller, Marc Leibundgut, Nenad Ban & Eilika Weber-Ban
NATURE COMMUNICATIONS | (2019) 10:4653 | |

A Reader-Based Assay for m6A Writers and Erasers
Lars Wiedmer, Stefanie Alexandra Eberle, Rajiv Kumar Bedi, Paweł Śledź and Amedeo Caflisch
Anal Chem. 2019 Feb 19;91(4):3078-3084. DOI:10.1021/acs.analchem.8b05500

Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins
Matthew Dunne, Beatrice Rupf, Marc Tala, Xhem Qabrati, Patrick Ernst, Yang Shen, Eric Sumrall, Laura Heeb, Andreas Pluckthun, Martin J. Loessner, and Samuel Kilcher
Cell Reports 29, 1336–1350, October 29, 2019,

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré & Andreas Plückthun
Nature Communications (2019) 10:17; doi: 10.1038/s41467-018-07939-8

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a
Daan C. Swarts, Martin Jinek
Molecular Cell 73, 1–12; doi: 10.1016/j.molcel.2018.11.021

Drug design inspired by Nature: Crystallographic detection of auto-tailored protease inhibitor template
Flavio M. Gall, Deborah Hohl, David Frasson, Tobias Wermelinger, Peer R. E. Mittl, Martin Sievers, and Rainer Riedl
Angew. Chem. Int. Ed.; doi: 10.1002/anie.201812348

Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme
H. Adrian Bunzel, Hajo Kries, Luca Marchetti, Cathleen Zeymer, Peer R. E. Mittl, Adrian J. Mulholland, and Donald Hilvert
J. Am. Chem. Soc. 2019, 141, 30, 11745–11748; DOI:10.1021/jacs.9b02731

Structural basis and mechanism for metallochaperone-assisted assembly of the CuA center in cytochrome oxidase
Fabia Canonica, Daniel Klose, Raphael Ledermann, Maximilian M. Sauer, Helge K. Abicht, Nick Quade, Alvar D. Gossert, Serge Chesnov, Hans-Martin Fischer, Gunnar Jeschke, Hauke Hennecke,Rudi Glockshuber
Science Advances  31 Jul 2019:Vol. 5, no. 7, eaaw8478; DOI:10.1126/sciadv.aaw8478