Structure Gallery 2020

The following structures have been solved using our high throughput crystallization services:

Structural and Dynamic Insights into Redundant Function of YTHDF Proteins
Yaozong Li, Rajiv K Bedi, Elena V Moroz-Omori, Amedeo Caflisch
J Chem Inf Model; Oct 19. 2020
PMID: 33073985DOI: 10.1021/acs.jcim.0c01029


Crystal structure of the human oxytocin receptor
Yann Waltenspühl, Jendrik Schöppe, Janosch Ehrenmann, Lutz Kummer, Andreas Plückthun
Science Advances  15 Jul 2020:Vol. 6, no. 29, eabb5419; DOI: 10.1126/sciadv.abb5419


Small‐Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer
Rajiv K. Bedi, Danzhi Huang, Stefanie A. Eberle, Lars Wiedmer, Pawel Śledź, Amedeo Caflisch
ChemMedChem 2020, 15, 744–748. doi.org/10.1002/cmdc.202000011


Structure-Guided Design of a Peptide Lock for Modular Peptide Binders
Patrick Ernst, Franziska Zosel, Christian Reichen, Daniel Nettels, Benjamin Schuler, Andreas Plückthun
ACS Chem. Biol. 2020, 15, 2, 457–468; DOI: 10.1021/acschembio.9b00928


Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling
Riccardo Rubbiani, Wenyu Wu, Anu Naik, Michele Larocca, Lukas Schneider, Roxane Padrutt, Vipin Babu, Christiane König, Doris Hinger, Caroline Maake, c Stefano Ferrari, Gilles Gasser and Bernhard Spingler
Chem. Commun., 2020, 56, 14373--14376, DOI: 10.1039/d0cc05196a


The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization
Ramon Hochstrasser, Cedric A. J. Hutter, Fabian M. Arnold, Kevin Bärlocher, Markus A. Seeger, Hubert Hilbi
Molecular Microbiology. 2020;113:1070–1084; DOI: 10.1111/mmi.14477 


Structural basis for ion selectivity in TMEM175 K+ channels
Janine D Brunner, Roman P Jakob, Tobias Schulze, Yvonne Neldner, Anna Moroni, Gerhard Thiel, Timm Maier, Stephan Schenck
eLife 2020;9:e53683. DOI: doi.org/10.7554/eLife.53683


Stereochemical Purity Can Induce a New Crystalline Mesophase in Phytantriol Lipids
Jijo J. Vallooran, Michael Duss, Philipp Ansorge, Raffaele Mezzenga, and Ehud M. Landau
Langmuir 2020, 36, 9132−9141; dx.doi.org/10.1021/acs.langmuir.0c01344


The ABC exporter IrtAB imports and reduces mycobacterial siderophores
Fabian M. Arnold, Miriam S. Weber, Imre Gonda, Marc J. Gallenito, Sophia Adenau, Pascal Egloff, Iwan Zimmermann, Cedric A. J. Hutter, Lea M. Hürlimann, Eike E. Peters, Jörn Piel, Gabriele Meloni, Ohad Medalia & Markus A. Seeger
Nature | Vol 580 | 16 April 2020 | 413; doi.org/10.1038/s41586-020-2136-9