Publications of the Medalia Group

2023

Buxboim, A., Kronenberg-Tenga, R., Salajkova, S., Avidan, N., Shahak, H., Thurston, A. & Medalia, O. Scaffold, mechanics and functions of nuclear lamins. FEBS Lett [Epub ahead of print] (2023). PMID: 37813648.

Franz, F., Tapia-Rojo, R., Winograd-Katz, S., Boujemaa-Paterski, R., Li, W., Unger, T., Albeck, S., Aponte-Santamaria, C., Garcia-Manyes, S., Medalia, O., Geiger, B. & Gräter, F. Allosteric activation of vinculin by talin. Nat Commun 14, 4311 (2023). PMID: 37463895.

Geiger, B., Boujemaa-Paterski, R., Winograd-Katz, SE., Balan Venghateri, J., Chung, WL. & Medalia, O. The Actin Network Interfacing Diverse Integrin-Mediated Adhesions. Biomolecules 13, (2023). PMID: 36830665.

Karoutas, A., Szymanski, W., Rausch, T., Guhathakurta, S., Rog-Zielinska, EA., Peyronnet, R., Seyfferth, J., Chen, HR., de Leeuw, R., Herquel, B., Kimura, H., Mittler, G., Kohl, P., Medalia, O., Korbel, JO. & Akhtar, A. Author Correction: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nat Cell Biol 25, 626 (2023). PMID: 36849559.

Li, W., Chung, WL., Kozlov, MM., Medalia, O., Geiger, B. & Bershadsky, AD. Chiral growth of adherent filopodia. Biophys J 122, 3704-3721 (2023). PMID: 37301982.

Tapia-Rojo, R., Mora, M., Board, S., Walker, J., Boujemaa-Paterski, R., Medalia, O. & Garcia-Manyes, S. Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape. Nat Phys 19, 52-60 (2023). PMID: 36660164.

Wang, C., Wojtynek, M. & Medalia, O. Structural investigation of eukaryotic cells: From the periphery to the interior by cryo-electron tomography. Adv Biol Regul 87, 100923  (2023). PMID: 36280452.

Wimmer, BH., Moraïs, S., Zalk, R., Mizrahi, I. & Medalia, O. Phylogenetic diversity of core rumen microbiota as described by cryo-ET. Microlife 4, uqad010 (2023). PMID: 37223726.

2022

Anand, U., Shteinfer-Kuzmine, A., Sela, G., Santhanam, M., Gottschalk, B., Boujemaa-Paterski, R., Medalia, O., Graier, WF. & Shoshan-Barmatz, V. The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide. Biomolecules 12, (2022). PMID: 36291596.

Beales, CT. & Medalia, O. Gold nanomaterials and their potential use as cryo-electron tomography labels. J Struct Biol 214, 107880 (2022). PMID: 35809758.

Chung, WL., Eibauer, M., Li, W., Boujemaa-Paterski, R., Geiger, B. & Medalia, O. A network of mixed actin polarity in the leading edge of spreading cells. Commun Biol 5, 1338 (2022). PMID: 36473943.

de Leeuw, R., Kronenberg-Tenga, R., Eibauer, M. & Medalia, O. Filament assembly of the C. elegans lamin in the absence of helix 1A. Nucleus 13, 49-57 (2022). PMID: 35130129.

Dultz, E., Wojtynek, M., Medalia, O. & Onischenko, E. The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth. Cells 11, (2022). PMID: 35563762.

Kono, Y., Adam, SA., Sato, Y., Reddy, KL., Zheng, Y., Medalia, O., Goldman, RD., Kimura, H. & Shimi, T. Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. J Cell Biol 221, (2022). PMID: 36301259.

Kralt, A., Wojtynek, M., Fischer, JS., Agote-Aran, A., Mancini, R., Dultz, E., Noor, E., Uliana, F., Tatarek-Nossol, M., Antonin, W., Onischenko, E., Medalia, O. & Weis, K. An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in <i>S. cerevisiae</i>. Elife 11, (2022). PMID: 36000978.

Tatli, M., Moraïs, S., Tovar-Herrera, OE., Bomble, YJ., Bayer, EA., Medalia, O. & Mizrahi, I. Nanoscale resolution of microbial fiber degradation in action. Elife 11, (2022). PMID: 35638899.

Vahabikashi, A., Adam, SA., Medalia, O. & Goldman, RD. Nuclear lamins: Structure and function in mechanobiology. APL Bioeng 6, 011503 (2022). PMID: 35146235.

Waltenspühl, Y., Ehrenmann, J., Vacca, S., Thom, C., Medalia, O. & Plückthun, A. Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nat Commun 13, 4153 (2022). PMID: 35851571.

Wu, H., Shen, Y., Sivagurunathan, S., Weber, MS., Adam, SA., Shin, JH., Fredberg, JJ., Medalia, O., Goldman, R. & Weitz, DA. Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex. Proc Natl Acad Sci U S A 119, e2115217119 (2022). PMID: 35235449

2021
Kittisopikul, M., Shimi, T., Tatli, M., Tran, JR., Zheng, Y., Medalia, O., Jaqaman, K., Adam, SA. & Goldman, RD. Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins. J Cell Biol 220, (2021). PMID: 33570570.

Kronenberg-Tenga, R., Tatli, M., Eibauer, M., Wu, W., Shin, JY., Bonne, G., Worman, HJ. & Medalia, O. A lamin A/C variant causing striated muscle disease provides insights into filament organization. J Cell Sci 134, (2021). PMID: 33536248.

Li, W., Sancho, A., Chung, WL., Vinik, Y., Groll, J., Zick, Y., Medalia, O., Bershadsky, AD. & Geiger, B. Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates. J Cell Sci 134, (2021). PMID: 33722978.

Martins, B., Sorrentino, S., Chung, WL., Tatli, M., Medalia, O. & Eibauer, M. Unveiling the polarity of actin filaments by cryo-electron tomography. Structure 29, 488-498.e4 (2021). PMID: 33476550.

Sapra, KT. & Medalia, O. Bend, Push, Stretch: Remarkable Structure and Mechanics of Single Intermediate Filaments and Meshworks. Cells 10, (2021). PMID: 34440729.

Schuller, AP., Wojtynek, M., Mankus, D., Tatli, M., Kronenberg-Tenga, R., Regmi, SG., Dip, PV., Lytton-Jean, AKR., Brignole, EJ., Dasso, M., Weis, K., Medalia, O. & Schwartz, TU. The cellular environment shapes the nuclear pore complex architecture. Nature 598, 667-671 (2021). PMID: 34646014.

Sorrentino, S., Conesa, JJ., Cuervo, A., Melero, R., Martins, B., Fernandez-Gimenez, E., de Isidro-Gomez, FP., de la Morena, J., Studt, JD., Sorzano, COS., Eibauer, M., Carazo, JM. & Medalia, O. Structural analysis of receptors and actin polarity in platelet protrusions. Proc Natl Acad Sci U S A 118, (2021). PMID: 34504018.

Thom, C., Ehrenmann, J., Vacca, S., Waltenspühl, Y., Schöppe, J., Medalia, O. & Plückthun, A. s proteins reveal substance P binding mode and unique activation features. Sci Adv 7, eabk2872 (2021). PMID: 34878828.

Weber, MS., Eibauer, M., Sivagurunathan, S., Magin, TM., Goldman, RD. & Medalia, O. Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy. Elife 10, (2021). PMID: 34323216.

2020
Arnold, FM., Weber, MS., Gonda, I., Gallenito, MJ., Adenau, S., Egloff, P., Zimmermann, I., Hutter, CAJ., Hürlimann, LM., Peters, EE., Piel, J., Meloni, G., Medalia, O. & Seeger, MA. The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature 580, 413-417 (2020). PMID: 32296173.

Bertrand, AT., Brull, A., Azibani, F., Benarroch, L., Chikhaoui, K., Stewart, CL., Medalia, O., Ben Yaou, R. & Bonne, G. LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery-Dreifuss Muscular Dystrophy. Cells 9, (2020). PMID: 32244403.

Boujemaa-Paterski, R., Martins, B., Eibauer, M., Beales, CT., Geiger, B. & Medalia, O. Talin-activated vinculin interacts with branched actin networks to initiate bundles. Elife 9, (2020). PMID: 33185186.

Horev, MB., Zabary, Y., Zarka, R., Sorrentino, S., Medalia, O., Zaritsky, A. & Geiger, B. Differential dynamics of early stages of platelet adhesion and spreading on collagen IV- and fibrinogen-coated surfaces. F1000Res 9, (2020). PMID: 32566134.

Khayat, M., Deri, S., Wolf, D., Trigano, T., Medalia, O. & Ben-Harush, K. Biomimetic nuclear lamin fibers with remarkable toughness and stiffness. Int. J. Biol. Macromol.163, 2060-2067 (2020). PMID: 32961198.

Sapra, KT., Qin, Z., Dubrovsky-Gaupp, A., Aebi, U., Müller, DJ., Buehler, MJ. & Medalia, O. Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina. Nat Commun 11, 6205 (2020). PMID: 33277502.

Stivala, S., Sorrentino, S., Gobbato, S., Bonetti, NR., Camici, GG., Lüscher, TF., Medalia, O. & Beer, JH. Glycoprotein Ib clustering in platelets can be inhibited by α-linolenic acid as revealed by cryo-electron tomography. Haematologica 105, 1660-1666 (2020). PMID: 31439672.

Tenga, R. & Medalia, O. Structure and unique mechanical aspects of nuclear lamin filaments. Curr Opin Struct Biol 64, 152-159 (2020). PMID: 32810798.

2019
Karoutas, A., Szymanski, W., Rausch, T., Guhathakurta, S., Rog-Zielinska, EA., Peyronnet, R., Seyfferth, J., Chen, HR., de Leeuw, R., Herquel, B., Kimura, H., Mittler, G., Kohl, P., Medalia, O., Korbel, JO. & Akhtar, A. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nat. Cell Biol. 21, 1248-1260 (2019). PMID: 31576060.

Qi, C., Sorrentino, S., Medalia, O. & Korkhov, VM. The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science 364, 389-394 (2019). PMID: 31023924.
Weber, MS., Wojtynek, M. & Medalia, O. Cellular and Structural Studies of Eukaryotic Cells by Cryo-Electron Tomography. Cells 8, (2019). PMID: 30654455.

2018
Chorev, DS., Volberg, T., Livne,  A., Eisenstein, M., Martins, B., Kam, Z., Jockusch, BM., Medalia, O., Sharon, M. & Geiger, B. Conformational states during vinculin unlocking differentially regulate focal adhesions properties. Sci Rep 8, 2693 (2018). PMID: 29426917.

Dahan, I., Sorrentino, S., Boujemaa-Paterski, R. & Medalia, O.Troponin-protected gold nanoparticles as a potential marker for cryo-EM and tomography. Structure 26, 1408-1413 (2018). PMID: 30078643.

de Leeuw, R., Gruenbaum, Y. & Medalia, O. Nuclear lamins: thin filaments with major functions. Trends Cell Biol. 28, 34-45 (2018). PMID: 28893461.

Lickert, S., Sorrentino, S., Studt, JD., Medalia, O., Vogel, V. & Schoen, I. Morphometric analysis of spread platelets identifies integrin alphaIIbbeta3-specific contractile phenotype. Sci Rep. 8, 5428 (2018). PMID: 29615672.

Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, UF., Medalia, O, & Plückthun, A. Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun 9, 450 (2018). PMID: 29386504.

Stritt, S., Birkholz, I., Beck, S., Sorrentino, S., Sapra, KT., Viaud, J., Heck, J., Gaits-Iacovoni, F., Schulze, H., Du, X., Hartwig, JH., Braun, A., Bender, M., Medalia, O. & Nieswandt, B. Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. Blood Adv. 2, 1040-1045 (2018). PMID: 29739775.

Tatli, M. & Medalia, O. Insight into the functional organization of nuclear lamins in health and disease. Curr Opin Cell Biol. 54, 72-79 (2018). PMID: 29800922.

2017
Malka-Gibor, E., Kornreich, M., Laser-Azogui, A., Doron, O., Zingerman-Koladko, I., Harapin, J., Medalia, O. & Beck, R. Phosphorylation-Induced Mechanical Regulation of Intrinsically Disordered Neurofilament Proteins. Biophys. J. 112, 892-900 (2017). PMID: 28297648.

Turgay, Y. & Medalia, O. The structure of lamin filaments in somatic cells as revealed by cryo-electron tomography. Nucleus 8, 475-481 (2017). PMID: 28635493.

Turgay, Y., Eibauer, M., Goldman, AE., Shimi, T., Khayat, M., Ben-Harush, K., Dubrovsky-Gaupp, A., Sapra, KT., Goldman, RD. & Medalia, O. The molecular architecture of lamins in somatic cells. Nature 543, 261-264 (2017). PMID: 28241138.

2016
Dubey, GP., Malli Mohan, GB., Dubrovsky, A., Amen, T., Tsipshtein, S., Rouvinski, A., Rosenberg, A., Kaganovich, D., Sherman, E., Medalia, O. & Ben-Yehuda, S. Architecture and Characteristics of Bacterial Nanotubes. Dev. Cell 36, 453-61 (2016). PMID: 26906740.

Irobalieva, RN., Martins, B. & Medalia, O. Cellular structural biology as revealed by cryo-electron tomography. J. Cell. Sci. 129, 469-76 (2016). PMID: 26787742.

Sorrentino, S., Studt, JD., Bokstad Horev, M., Medalia, O. & Sapra, KT. Toward correlating structure and mechanics of platelets. Cell Adh Migr 10, 568-575 (2016). PMID: 27104281.

Tamir, A., Sorrentino, S., Motahedeh, S., Shai, E., Dubrovsky, A., Dahan, I., Eibauer, M., Studt, JD., Tanuj Sapra, K., Varon, D. & Medalia, O. The macromolecular architecture of platelet-derived microparticles. J. Struct. Biol. (J. Struct. Biol. 193, 181-7 (2016). PMID: 26767592.

Zingerman-Koladko, I., Khayat, M., Harapin, J., Shoseyov, O., Gruenbaum, Y., Salman, A., Medalia, O. & Ben-Harush, K. The assembly of C. elegans lamins into macroscopic fibers. J Mech Behav Biomed Mater 63, 35-43 (2016). PMID: 27341289.

Zuela, N., Zwerger, M., Levin, T., Medalia, O. & Gruenbaum, Y. Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation. J. Cell. Sci. 129, 1781-91 (2016). PMID: 27034135.

Zwerger, M., Eibauer, M. & Medalia, O. Insights into the gate and scaffold of the nuclear pore complex. Nucleus  7, 1-7 (2016). PMID: 26902931.

2015
Dubrovsky, A., Sorrentino, S., Harapin, J., Sapra, KT. & Medalia, O. Developments in cryo-electron tomography for in situ structural analysis. Arch.  Arch. Biochem. Biophys. 581, 78-85 (2015). PMID: 25921875.

Eibauer, M., Pellanda, M., Turgay, Y., Dubrovsky, A., Wild, A. & Medalia, O. Structure and gating of the nuclear pore complex. Nat Commun 6, 7532 (2015). PMID: 26112706.

Gruenbaum, Y. & Medalia, O. Lamins: the structure and protein complexes. Curr. Opin. Cell Biol. 32, 7-12 (2015). PMID: 25460776.

Harapin, J., Börmel, M., Sapra, KT., Brunner, D., Kaech, A. & Medalia, O. Structural analysis of multicellular organisms with cryo-electron tomography. Nat. Methods 12, 634-6 (2015). PMID: 25961413.

Sorrentino, S., Studt, JD., Medalia, O. & Tanuj Sapra, K. Roll, adhere, spread and contract: structural mechanics of platelet function. Eur. J. Cell Biol. 94, 129-38 (2015). PMID: 25655000.

Zwerger, M., Roschitzki-Voser, H., Zbinden, R., Denais, C., Herrmann, H., Lammerding, J., Grütter, MG. & Medalia, O. Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins. J. Cell. Sci. 128, 3607-20 (2015). PMID: 26275827.

2013
Elad, N, Volberg, T., Patla, I., Hirschfeld-Warneken, V., Grashoff, C., Spatz, JP., Fässler, R., Geiger, B. & Medalia, O. The role of integrin-linked kinase in the molecular architecture of focal adhesions. J Cell Sci. 126, 4099-4107 (2013).

Harapin, J., Eibauer, M. & Medalia, O. Structural analysis of supramolecular assemblies by cryo-electron tomography. Structure 21, 1522-30 (2013).

Lavelin, I., Wolfenson, H., Patla, I., Henis, YI., Medalia, O., Volberg, T., Livne, A., Kam, Z. & Geiger, B. Differential effect of actomyosin relaxation on the dynamic properties of focal adhesion proteins. PLoS ONE 8, e73549 (2013).

Sandler, I., Medalia, O. & Aharoni, A. Experimental analysis of co-evolution within protein complexes: the yeast exosome as a model. Proteins 81, 1997-2006 (2013).

Zwerger, M. & Medalia, O. From lamins to lamina: a structural perspective. Histochem Cell Biol. 140, 3-12 (2013).

2012
Bank, EM., Ben-Harush, K.,  Feinstein, N., Medalia, O. & Gruenbaum, Y. Structural and physiological phenotypes of disease-linked lamin mutations in C. elegans. J Struct. Biol. 177, 106-112 (2012).

Bokstad, M., Sabanay, H., Dahan, I., Geiger, B. & Medalia, O. Reconstructing adhesion structures in tissues by cryo-electron tomography of vitrified frozen sections. J. Struct. Biol. 178, 76-83 (2012).

Fridmann, K., Mader, A., Zwerger, M., Elia, N. & Medalia, O. Advances in tomography: probing the molecular architecture of cells. Nat Rev. Mol Cell Biol. 13, 736-742 (2012).

Grossman, E., Dahan, I., Stick, R., Goldberg, MW., Gruenbaum, Y. & Medalia, O. Filament assembly of ectopically expressed Caenorhabditis elegans lamin within Xenopus oocytes. J. Struct. Biol. 177, 113-118 (2012).

Grossmann, E., Medalia, O. & Zwerger, M. Functional architecture of the nuclear pore complex. Annu Rev Biophys. 41, 557-584 (2012).

Henderson, R, Sali, A, Baker, ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ & Lawson CL. Outcome of the first electron microscopy validation task force meeting. Structure 20, 205-2014 (2012).

Maimon, T., Elad, N., Dahan, I. & Medalia, O. The human nuclear pore complex as revealed by cryo-electron tomography. Structure 20, 998-1006 (2012).

Medalia, O., & Frangakis, A. Special issue on electron tomography. J Struct Biol. 178, 75 (2012).

Rigort, A., Günther, D., Hegert, R., Baum, D., Weber, B., Prohaska, S., Medalia, O., Baumeister, W. & Hege, HC. Automated segmentation of electron tomograms for a quantitative description of actin filament networks. J Struct Biol. 177, 135-144 (2012).

Zwerger, M. & Medalia, O. Unravelling the lamina network. Nat. Rev. Mol. Cell Biol. 13, 140 (2012).

2011
Bank, EM., Ben-Harush, K., Wiesel-Motiuk, N., Barkan, R., Feinstein, N., Lotan, O., Medalia, O. & Gruenbaum, Y. A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in C. elegans. Mol Biol Cell. 22, 2716-2728 (2011).

Elad, N., Abramovitch, S., Sabanay, H. & Medalia, O. Microtubule organization in the final stages of cytokinesis as revealed by cryo-electron tomography. J Cell Sci. 124, 207-215 (2011). 

Tamir, A., Elad, N. & Medalia, O. Assembly and breakdown of microtubules within the midbody. Commun Integr. Biol. 5, 552-553 (2011). 

Yahav, T., Maimon, T., Grossman, E., Dahan, I. & Medalia, O. Cryo-electron tomography: gaining insight into cellular processes by strcutural approaches. Curr Opin Struct Biol. 21, 670-677 (2011).

2010
Ben-Harush, K., Maimon T., Villa, E. & Medalia, O. Visualizing cellular processes at the molecular level by cryo-electron tomography. J. Cell Sci. 123, 7-12 (2010). 

Frenkiel-Krispin, D., Mako, B., Aebi, U. &  Medalia, O. Structural analysis of a metazoan nuclear pore complex reveals fused concentric rings architecture. J. Mol. Biol. 395, 578-586 (2010). 

Mader, A., Ekad, N. & Medalia, O. Cryoelectron tomography of eukaryotic cells. Methods Enzymol. 483, 245-265 (2010). 

Maimon, T. & Medalia, O. Perspective on the metazoan nuclear pore complex. Nucleus 1, 383-386 (2010). 

Medalia, O. & Geiger, B. Frontiers of microscopy-based research into cell-matrix adhesions. Curr Opin Cell Biol. 22, 659-668 (2010).

Patla, I., Volberg, T., Elad, N., Hirschfeld-Warneken,V., Grashoff, C., Fässler, R., Spatz, JP., Geiger, B. & Medalia, O. Dissecting molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol. 12, 909-915 (2010).

2009
Ben-Harush, K., Wiesel, N., Frenkiel-Krispin, D., Herrmann, H., Aebi, U., Gruenbaum, Y. & Medalia, O. Dissecting the supramolecular organization of the nuclear lamin filaments and paracrystalline fibers. J. Mol. Biol. 386, 1392-13402 (2009).

Böttcher, R., Wiesner, S., Braun, A., Wimmer, R., Berna, A., Elad, E., Medalia, O., Pfeifer, A., Aszódi, A., Costell, M. &  Fässler, R.  Profilin 1 is required for midbody separation during late cytokinesis of chondrocytes.  EMBO J. 28, 1157-1169 (2009).

Elad N., Maimon T., Frenkiel-Krispin, D., Lim R.Y.H. & Medalia, O. Structural analysis of the nuclear pore complex by integrated approaches. Curr Opin Struct Biol. 19, 226-232 (2009).

Konorty, M., Kahana, N., Brumfeld, V., Vermiglio, A., Medalia, O. & Minsky, A. Photosynthetic system in Blastochloris viridis revisited. Biochem.  48, 4753-4761 (2009).

Lieber, A., Kushmaro, A., Minsky A. & Medalia, O. (2009) Chromatin organization and radio-resistance in the bacterium Gemmata obscuriglobus.  J. Bacteriol. 191, 1439-1445 (2009). 

Medalia, N.,  Beer, A., Zwickl, P., Mihalache, O., Beck, M., Medalia, O. & Navon, A. Architecture and molecular mechanism of PAN, the archaeal proteasome regulatory ATPase.  J Biol. Chem. 284, 22952-22960 (2009).

Taimen, P., Pfleghaar, K., Shimi, T., Möller, D., Ben-Harush, K., Erdos, MR., Adam, SA., Herrmann, H., Medalia, O., Collins, F., Goldman, AE. & Goldman, R.  A progeria mutation reveals functions for lamin A in nuclear assembly, architecture and chromosome organization. Proc Natl. Acad. Sci. U.S.A. 106, 20788-20793 (2009).

2008
Beck, M. & Medalia, O. Structural and functional insights into nucleocytoplasmic transport. Histol. Histopathol. 23, 1025-1033 (2008).

Gruska, M., Medalia, O., Baumeister, W. &  Leis, A. Electron tomography of vitreous sections from cultured mammalian cells.  J. Struct. Biol. 161,  383-392 (2008).       

Konorty, M., Kahana, N., Linaroudis, A., Minsky, A. &  Medalia, O. Structural analysis of photosynthetic membranes by cryo-electron tomography of intact Rhodopseudomonas viridis cells. J. Struct. Biol. 161, 393-400 (2008).

Marko, M., Ellisman, M. & Medalia, O. The 4th international conference on electron tomography. Editorial.  J. Struct. Biol. 161, 219 (2008).

Wiesel, N.,  Mattout, A., Melcer, S., Melamed-Book, N., Herrmann, H., Medalia, O., Aebi, U. & Gruenbaum, Y.  Laminopathic mutations interfere with the assembly, localization and dynamics of nuclear lamins. Proc Natl. Acad. Sci. U.S.A. 105, 180-185 (2008).

2007
Abu-Qarn, M., Yurist, S., Giordano,S., Trauner, A., Morris, H.R., Hitchen, P., Medalia, O., Dell, A. & Eichler, J.  Haloferax volcanii AglB and AglD are involved in N-glycosylation of the S-layer glycoprotein and proper assembly of the surface layer. J. Mol. Bio 374, 1224-1236 (2007).

Beck, M., Lucic, V., Förster, F.,  Baumeister, W. & Medalia, O. Snapshots of nuclear pore complexes in action captured by cryoelectron tomography. Nature  449, 611-615  (2007).   

Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister,W. Gerisch, G.  Organization of actin networks in intact filopodia. Curr. Biol. 17, 79-84 (2007).

2006
Medalia, N., Sharon, M., Martinez-Arias, R., Mihalache, O,, Robinson, CV, Medalia, O. & Zwickl, P. Functional and structural characterization of the Methanosarcina mazei proteasome and PAN complexes. J. Struct. Biol. 156, 84-92 (2006).            

2005
Förster, F., Medalia, O., Zauberman, N., Baumeister, W., & Fass, D. Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography. Proc Natl. Acad. Sci. U.S.A. 102, 4729-4734 (2005).  

2004
Beck, M., Forster, F., Ecke, M., Plitzko, JM., Melchior, F., Gerisch, G., Baumeister, W. &  Medalia, O.  Nuclear pore complex structure and dynamics revealed by cryoelectron tomography.  Science 306, 1387-90 (2004). 

Kürner, J., Medalia O.,  Linaroudis, AA. & Baumeister, W. New insights into the structural organization of eukaryotic and prokaryotic cytoskeletons using cryo-electron tomography. Exp. Cell Res. 301, 38-42 (2004).

2003
Uhle, U., Medalia, O., Dumdey, R., Henklein, P., Bech-Otschir, D., Berndt, C., Berse, M., Sperling, J. &  Dubiel, W. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.  EMBO J. 22, 1302-131 (2003).

2002
Bretschneider, T., Jonkman, J., Köhler, J., Medalia, O., Weber, I., Stelzer, E., Baumeister, W. & Gerisch, G.  Dynamic organization of the actin system in the motile cells of Dictyostelium. J Muscle Res Cell Motil. 23, 639-649 (2002) .

Grünewald, K., Medalia, O., Gross, A., Steven, A.C. & Baumeister, W. Prospects of electron cryotomography to visualize macromolecular complexes inside cellular compartments: implications of crowding. Biophys. Chem. 100, 577-591 (2002) .

Medalia, O., Weber, I., Frangakis, A.S., Nicastro, D., Gerisch, G. & Baumeister, W. Macromolecular architecture in eukaryotic cells visualized by cryo-electron tomography.  Science 298, 1209-1213 (2002).

Medalia, O., Typke, D., Hegerl R., Angenitzki M., Sperling, J. & Sperling, R. Cryo-electron microscopy and cryo-electron tomography of the nuclear pre-mRNA processing machine. J. Struct. Biol. 138, 74-84 (2002).

Medalia, O., Englander, J., Guckenberger, R. & Sperling, J. Anchoring of DNA to a gold surface facilitates the imaging of protein-DNA complexes by atomic force microscopy in solution, Ultramicroscopy 90, 103-112 (2002).

2001
Henn, A., Medalia, O., Shu-Ping, S., Franceschi, F.  & Sagi, I. Demonstrating of unwinding activity of duplex RNA by DbpA, a DEAD box helicase, at single molecule level. Proc Natl. Acad. Sci. U.S.A  98,  5007-5012 (2001).

2000
Hölzl, H., Kapelari B,. Kellermann J., Seemuller E,. Sumegi M., Udvardy A., Medalia O., Sperling J, Muller S.A., Engel A. &  Baumeister, W. . The regulatory complex of Drosophila melanogaster 26S proteasomes: Subunit composition and localization of a deubiquitylating enzyme, J Cell Biol. 150, 119-130 (2000).

1999
Medalia, O., Heim, M., Guckenberger, R., Sperling, R. & Sperling, J.  Gold tagged RNA- A probe for RNP complexes, J. Struct. Biol. 127, 113-119 (1999).

1997
Medalia, O., Koster, A., Tocilj, A., Angenitzki, M., Sperling, J., Berkovitch-Yellin, Z. & Sperling, R. Automated electron tomography of large nuclear RNP (lnRNP) particles - the naturally assembled complexes of precursor messenger RNA and splicing factors.  J. Struct. Biol. 120, 228-236 (1997).