The
Plückthun
Lab

Structures

List of structures determined in collaboration with the Plückthun lab. Click on the link on the left to see an animation of the structure, and the abstract of the publication with link to the PDF. Links to the PDB and to the summary on PDBsum are provided as well.

Details Title Method
2IMM Antibody McPC603 light chain variable domain mutant x-ray
2IMN Antibody McPC603 light chain variable domain x-ray
1G3P Crystal structure of the N-terminal domains of bacteriophage minor coat protein g3p x-ray
1C12 Antibody Fab fragment x-ray
1C5E Bacteriophage lambda head protein D x-ray
1FG2 Crystal structure of the LCMV peptidic epitope gp33 in complex with the murine class I MHC molecule H-2Db x-ray
1H8N Three-dimensional structure of anti-ampicillin single-chain Fv fragment from phage-displayed murine antibody libraries x-ray
1H8O Three-dimensional structure of anti-ampicillin single-chain Fv fragment x-ray
1H8S Three-dimensional structure of anti-ampicillin single-chain Fv fragment complexed with the hapten x-ray
1I3G Crystal structure of an ampicillin single-chain Fv fragment, form 1, free x-ray
1IHR Crystal structure of the dimeric C-terminal domain of TonB x-ray
1JPF Crystal structure of the LCMV peptidic epitope gp276 in complex with the murine class I MHC molecule H-2Db x-ray
1JPG Crystal structure of the LCMV peptidic epitope np396 in complex with the murine class I MHC molecule H-2Db x-ray
1KP5 Cyclic green fluorescent protein x-ray
1KTR Crystal structure of the anti-his tag antibody 3D5 single- chain fragment (scFv) in complex with a oligohistidine peptide x-ray
1MJ0 E3_5: An artificial ankyrin repeat protein (DARPin) x-ray
1N3N Crystal structure of a mycobacterial Hsp60 epitope with the murine class I MHC molecule H-2Db x-ray
1P4B Three-dimensional structure of a single chain Fv fragment complexed with the peptide GCN4 (7P-14P) x-ray
1P4I Crystal structure of scFv against peptide GCN4 x-ray
1SVX Designed Ankyrin repeat protein off7 (DARPin) x-ray
1TCZ Crystal structure of a truncated version of the phage lamda protein gdp x-ray
1TD0 Viral capsid protein SHP at pH 5.5 x-ray
1TD3 Crystal structure of the viral capsid protein SHP in space group C2 x-ray
1TD4 Crystal structure of the viral capsid protein SHP in space group H3 with high resolution x-ray
1TOL Fusion of N-terminal domain of the minor coat protein from gene III in phage M13, and C-terminal domain of E. coli protein TolA x-ray
1VD0 Phage lambda capsid stabilizing protein gpD, NMR, 20 Structures NMR
2A9M Antibody FitcE2, apo form x-ray
2A9N Antibody FitcE2, mutant designed to alter crystal packing, complex with fluorescein x-ray
2BKG Crystal structure of E3_19, a designed ankyrin repeat protein (DARPin) x-ray
2BKK Crystal structure of aminoglycoside phosphotransferase APH (3')-IIIA in complex with the inhibitor AR_3A (DARPin) x-ray
2HH0 Structure of an Anti-PrP Fab, P-clone, in complex with its cognate bovine peptide epitope x-ray
2JAB A designed ankyrin repeat protein evolved to picomolar affinity to HER2 (DARPin) x-ray
2P2C Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin) x-ray
2QYJ Crystal structure of a designed full consensus ankyrin (DARPin) with three internal repeats x-ray
2V7N CitS binding antibody Fab fragment F3P4 x-ray
3HG0 Crystal structure of a DARPin in complex with ORF49 from Lactococcal phage TP901-2 x-ray
2XEN Crystal structure of a designed full consensus DARPin with one internal repeat and extended C-terminal helix (mut4) x-ray
2XEE Crystal structure of designed full consensus DARPin with three internal repeats and reengineered C-capping module (mut5) x-ray
2XEH Crystal structure of designed full consensus DARPin with three internal repeats and reengineered C-capping module (mut6) x-ray
4DBA Designed Armadillo repeat protein, YIIM3AII x-ray
4DB9 Designed Armadillo repeat protein, YIIIM3AIII x-ray
4DB8 Designed Armadillo repeat protein, YIIM4AII x-ray
4DB6 Designed Armadillo repeat protein, YIIIM3AII x-ray
4DRX GTP-Tubulin in complex with a DARPIN x-ray
3ZU7 DARPin complexed to phosphorylated kinase pErk2 x-ray
3ZUV DARPin complexed to unphosphorylated kinase Erk2 x-ray
3ZEV Structure of signalling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli x-ray
4F6R Design and characterization of modular scaffolds for tubulin assembly x-ray
4F61 Design and characterization of modular scaffolds for tubulin assembly x-ray
4ATZ Development of a Generic Adenovirus Delivery System Based on Structure-Guided Design of Bispecific Trimeric Darpin Adapters x-ray
4HNA Structure of a kinesin-tubulin complex and implications for kinesin motility. x-ray
4K5A Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W x-ray
4K5B Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W x-ray
4BUO Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia Coli x-ray
4BV0 Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli x-ray
4BWB Structure of signalling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia Coli x-ray
4K5C From DARPins to LoopDARPins: novel LoopDARPins in design allows the selection of low picomolar binders in a single round of ribosome display x-ray
4HRL Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2 x-ray
4HRM Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2 x-ray
4HRN Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2 x-ray
2RU4 Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure x-ray
2RU5 Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure x-ray
4PLQ Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure x-ray
4PLR Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure x-ray
4PLS Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure x-ray
4V3O Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap x-ray
4V3Q Designed armadillo repeat protein with 4 internal repeats, 2nd generation C-cap and 3rd generation N-cap x-ray
4V3R Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap x-ray
5AEI Designed Armadillo repeat protein YIIIM5AII in complex with peptide (KR)5 x-ray
5AQ7 DARPin-based crystallization chaperones exploit molecular geometry as a screening dimension in protein crystallography x-ray
5AQ8 DARPin-based crystallization chaperones exploit molecular geometry as a screening dimension in protein crystallography x-ray
5AQ9 DARPin-based crystallization chaperones exploit molecular geometry as a screening dimension in protein crystallography x-ray
5AQA DARPin-based crystallization chaperones exploit molecular geometry as a screening dimension in protein crystallography x-ray
5AQB DARPin-based crystallization chaperones exploit molecular geometry as a screening dimension in protein crystallography x-ray
5EYL Tubulin-binding Darpin x-ray
5EYP Tubulin-Darpin Complex x-ray
5JS7 Structural Model of a apo G-protein alpha subunit determined with NMR residual dipolar couplings and SAXS x-ray
5JS8 Structural Model of a Protein alpha subunit in complex with GDP optained with SAXS and NMR residual couplings x-ray