Publications 2019

Click the number of a publication to read its abstract. For some of the publications supplementary files are available on the abstract page.

Number Reference PDF
0444 Heine, P., Witt, G., Gilardi, A., Gribbon, P., Kummer, L., and Plückthun, A. (2019). High-throughput fluorescence polarization assay to identify ligands using purified G-protein-coupled receptor. SLAS Discov. 24, 915-927.
0443 Brandl, F., Merten, H., Zimmermann, M., Behe, M., Zangemeister-Wittke, U., and Plückthun, A. (2019). Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins. J. Control. Release 307, 379-392.
0442 Merten, H., Schaefer, J. V., Brandl, F., Zangemeister-Wittke, U., and Plückthun, A. (2019). Facile site-specific multiconjugation strategies in recombinant proteins produced in bacteria. Methods Mol. Biol. 2033, 253-273.
0441 Zhang, Y., Auger, S., Schaefer, J. V., Plückthun, A., and Distefano, M. D. (2019). Site-selective enzymatic labeling of designed ankyrin repeat proteins using protein farnesyltransferase. Methods Mol. Biol. 2033, 207-219.
0440 Stüber, J. C., Kast, F., and Plückthun, A. (2019). High-throughput quantification of surface protein internalization and degradation. ACS Chem. Biol. 14, 1154-1163.
0439 Radom, F., Paci, E., and Plückthun, A. (2019). Computational modeling of designed ankyrin repeat protein complexes with their targets. J. Mol. Biol. 431, 2852-2868.
0438 Lorenzer, C., Streussnig, S., Tot, E., Winkler, A. M., Merten, H., Brandl, F., Sayers, E. J., Watson, P., Jones, A. T., Zangemeister-Wittke, U., Plückthun, A., and Winkler, J. (2019). Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. Eur. J. Pharm. Biopharm. 141, 37-50.
0437 Campanacci, V., Urvoas, A., Cantos-Fernandes, S., Aumont-Nicaise, M., Arteni, A. A., Velours, C., Valerio-Lepiniec, M., Dreier, B., Plückthun, A., Pilon, A., Pous, C., Minard, P., and Gigant, B. (2019). Insight into microtubule nucleation from tubulin-capping proteins. Proc. Natl. Acad. Sci. U. S. A. 116, 9859-9864.
0436 Meksiriporn, B., Ludwicki, M. B., Stephens, E. A., Jiang, A., Lee, H. C., Waraho-Zhmayev, D., Kummer, L., Brandl, F., Plückthun, A., and DeLisa, M. P. (2019). A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins. Nature communications 10, 1830.
0435 Andres, F., Iamele, L., Meyer, T., Stüber, J. C., Kast, F., Gherardi, E., Niemann, H. H., and Plückthun, A. (2019). Inhibition of the MET kinase activity and cell growth in MET-addicted cancer cells by bi-paratopic linking. J. Mol. Biol. 431, 2020-2039.
0434 Deprey, K., Becker, L., Kritzer, J., and Plückthun, A. (2019). Trapped! A critical evaluation of methods for measuring total cellular uptake versus cytosolic localization. Bioconjug. Chem. 30, 1006-1027.
0433 Tomatis, P. E., Schütz, M., Umudumov, E., and Plückthun, A. (2019). Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli. Sci. Rep. 9, 2483.
0432 Michel, E., Plückthun, A., and Zerbe, O. (2019). Peptide binding affinity redistributes preassembled repeat protein fragments. Biol. Chem. 400, 395-404.
0431 Schwill, M., Tamaskovic, R., Gajadhar, A. S., Kast, F., White, F. M., and Plückthun, A. (2019). Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2- positive breast cancer. Science Signaling 12, eaau2875.
0430 Kumar, A., and Plückthun, A. (2019). In vivo assembly and large-scale purification of a GPCR - G-alpha fusion with G-beta-gamma, and characterization of the active complex. PLoS One 14, e0210131. DOI: 10.1371/journal.pone.0210131
0429 Schöppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schütz, M., Dore, A. S., and Plückthun, A. (2019). Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nature Communications 10, 17;