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Department of Biochemistry

Calendar of Events


The UZH corona safety concept, dated 1.7.2021, mandates that a mask must be worn in all publicly accessible indoor areas. When delivering protein samples to PCC, you must wear a face mask from the moment you enter an UZH building.

Masks are mandatory in all publicly accessible indoor areas of UZH. This explicitly also applies to on-site seminars or lectures and to workspaces for independent study for which registration is not required.

Masks are no longer required in all workplaces (offices, laboratories, workshops, etc.) in indoor areas not accessible to the public, and at workspaces for independent study for which registration is required (e.g. in libraries), provided that the safety concepts are observed and the distance of 1.5m from other people can be maintained.

Masks are also no longer required in outdoor areas.

New screen:

Check out the new and improved EZ-Excel Screen Builder tool.

The Small Molecule Anion screen developed by Prof. Dr. Bernhard Spingler (UZH) is now available as GS086 .

Crystal Screen 1+2 Cryo GS084
Hampton Research screen detail: HR2-122 + HR2-121

The Ammonium sulfate screen GS002 has been newly designed and is now available as GS085.

What’s new:
PCC now additionally supports researchers with preparing custom screens through their pipetting service. The researcher can freely compose a screen with up to 30 different stock solutions.
Be sure to have a look and feel free to ask the PCC staff concerning this new service.

What's New in ROCK MAKER 3.17? Protein Crystallization Software Update ROCK MAKER® 3.17


Department of Biochemistry
University of Zurich
Winterthurerstr. 190
CH-8057 Zurich
Office: Y44 J 30/34

Beat Blattmann
Tel.: +41 44 635 6557

Protein Crystallization Center - PCC

The Protein Crystallization Center – PCC@UZH – supports the structural biology research community by setting up and monitor high-throughput protein crystallization experiments at the nano-liter scale. PCC@UZH offers as a service a wide range of crystallization techniques for soluble and membrane proteins. The crystallization service is open to all academic research groups and to private industry.

Proteins are the largest group of non-aqueous components in living cells. Almost every chemical reaction in a living cell requires a specific enzyme; this class of protein is also the most diverse. Knowing the 3-D structure of enzymes is vital to understand cellular processes. From the techniques used for the structure determination of macromolecules X-ray crystallography is the most productive method to date.
Crystals of a protein are prerequisite for structure determination by X-ray crystallography. Since the crystallization of bio molecules is a poorly understood process, high-throughput crystallization screening methods have to be used to find a successful condition for a new protein. Using vapor diffusion as the most common crystallization technique a combination of condition variables has to be determined for each protein. Condition variables are e.g. the protein concentration, the temperature, pH, and the concentration of a wide range of precipitation agents in combination with various salts. High throughput screening in combination with miniaturizing the crystallization experiment to 100nl is a practical solution for finding a suitable crystallization condition out of a large number of tests by using only a small amount of purified protein.

For more information how to get your protein crystallized go to:

CSIRO.au - User Guide:Collaborative Crystallisation Centre (C3)

Crystallization Protocol:Oxford Protein Production Facility - UK

Hampton Research: Crystal Growth 101 Literature

"Growing Crystals That Will Make Your Crystallographer Happy" by Paul D. Boyle