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Department of Biochemistry

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Publications of the Grütter Group

Morger, D., Zosel, F., Bühlmann, M., Züger, S., Mittelviefhaus, M., Schuler, B., Luban, J. &  Grütter, MG.The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5  alpha. J. Virol. 92(5), e01541-17 (2018).  PMID: 29237846.

Kramer, L., Renko, M., Završnik, J., Turk, D., Seeger, MA., Vasiljeva, O., Grütter, MG., Turk, V. & Turk, B. Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin. Theranostics 7, 2806-2821 (2017). PMID: 28824717.

Spalinger, MR., Kasper, S., Gottier, C., Lang, S., Atrott, K., Vavricka, SR., Scharl, S., Gutte, PM., Grütter, MG., Beer, HD., Contassot, E., Chan, AC., Dai, X., Rawlings, DJ., Mair, F., Becher, B., Falk, W., Fried, M., Rogler, G. & Scharl, M. NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J. Clin. Invest. 126, 1783-800 (2016). PMID: 27043286.

Reichen, C., Madhurantakam, C., Hansen, S., Grütter, MG., Plückthun, A. & Mittl, PR. Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects. Acta Crystallogr D Struct Biol 72, 168-75 (2016). PMID: 26894544.

Bukowska, MA., Hohl, M., Geertsma, ER., Hürlimann, LM., Grütter, MG. & Seeger, MA. A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter. Biochemistry 54, 3086-99 (2015). PMID: 25947941.

Weinert, C., Morger, D., Djekic, A., Grütter, MG. & Mittl, PR. Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers. Sci Rep 5, 10819 (2015). PMID: 26043233.

Zwerger, M., Roschitzki-Voser, H., Zbinden, R., Denais, C., Herrmann, H., Lammerding, J., Grütter, MG. & Medalia, O. Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins. J. Cell. Sci. 128, 3607-20 (2015). PMID: 26275827.

Flütsch, A., Ackermann, R., Schroeder, T., Lukarska, M., Hausammann, GJ., Weinert, C., Briand, C. & Grütter, MG. Combined inhibition of caspase-3 and caspase-7 by two highly selective DARPins slows down cellular demise. Biochem. J. 461, 279-90 (2014). PMID: 24779913.

Flütsch, A., Schroeder, T., Barandun, J., Ackermann, R., Bühlmann, M. & Grütter, MG. Specific targeting of human caspases using designed ankyrin repeat proteins. Biol. Chem. 395, 1243-52 (2014). PMID: 25153593.

Grütter, MG. Biocrystallography in Switzerland: achievements and future perspectives. Chimia (Aarau) 68, 54-9 (2014). PMID: 24801698.

Gutte, PG., Jurt, S., Grütter, MG. & Zerbe, O. Unusual Structural Features Revealed by the Solution NMR Structure of the NLRC5 Caspase Recruitment Domain. Biochemistry 53, 3106-17 (2014). PMID: 24815518.

Hohl, M., Hürlimann, LM., Böhm, S., Schöppe, J., Grütter, MG., Bordignon, E. & Seeger, MA. Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter. Proc. Natl. Acad. Sci. U.S.A. 111, 11025-30 (2014). PMID: 25030449.

Bonnet, M., Kurz, M., Mesa, S., Briand, C., Hennecke, H. & Grütter, MG. Structure of Bradyrhizobium japonicum transcription factor FixK2 unveils sites of DNA binding and oxidation. J Biol.Chem. 288, 14238-14246 (2013). 

Blomberg, R., Kries, H., Pinkas, DM., Mittl, PR., Grütter, MG., Privett, HK., Mayo, SL. & Hilvert, D. Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature 503, 418-21 (2013).

Bukowska, MA. & Grütter, MG. New concepts and aids to facilitate crystallization. Curr Opin Struct Biol. 23, 409-416 (2013).

Dreier, B., Honegger, A., Hess, C., Nagy-Davidescu, G., Mittl, PR., Grütter, MG., Belousova, N., Mekheeva, G., Krasnykh, V. & Plückthun, A. Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. PNAS USA 110, E869-877 (2013).

Hausammann, GJ. & Grütter, MG. Chimeric hERG Channels Containing a Tetramerization Domain are Functional and Stable. Biochemistry 52, 9237-45 (2013).

Hausammann, GJ., Heitkamp, T., Matile, H., Gsell, B., Thoma, R., Schmid, G., Frasson, D., Sievers, M., Hennig, M. & Grütter, MG. Generation of an antibody toolbox to characterize hERG. Biochem Biophys Res Commun. 431, 70-75 (2013).

Kebbel, F., Kurz, M., Arheit, M., Grütter, MG. & Stahlberg, H.Structure and substrate-induced conformational changes of the secondary citrate/ sodium symporter CitS revealed by electron crystallography. Structure 21, 1243-1250 (2013).

Schröder, T., Barandun, J., flütsch, A., Briand, C., Mittl, PR. & Grütter, MG. Specific inhibition of caspase-3 by a competitive DARPin: molecular mimicry between native and designed inhibitors. Structure 21, 277-289 (2013).

Seeger, MA., Zbinden, R., Flütsch, A., Gutte, PG., Engeler, S., Roschitzki-Voser, H. & Grütter, MG. Design, construction and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci. 22, 1239-1257 (2013).

Chodorge, M., Züger, S., Stirnimann, C., Briand, C., Jermutus, L., Grütter, MG. & Minter, RR. A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Diff. 19, 1187-1195 (2012).

Crespo, MD., Puorger, C., Schärer, MA., Eidam, O., Grütter, MG., Capitani, G. & Glockshuber, R. Quality control of disulfide bond formation in pilus subunits by the chaperone FimC. Nat Chem Biol. 8, 707-713 (2012).

Eicher,T., Cha, HJ., Seeger, MA., Brandstätter, L., El-Delik, J., Bohnert, JA., Kern WV., Verrey, F., Grütter, MG., Diederichs, K. & Pos, KM. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. PNAS 109, 5687-5692 (2012). 

Grütter, MG & Luban, J.TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling. Curr Opin Virol. 2, 142-150 (2012).

Heck,T., Merz, T., Reimer, A., Seebach, D., Rentsch, D., Briand, C., Grütter, MG., Kohler, HP. & Geueke, B. Crytsal structure of BapA complexes with beta-lactam-derived inhibitors illustrate substrate specificity and enantioselectivity of beta-aminopeptidases. Chembiochem. 13, 2137-2145 (2012).

Hohl M., Grütter MG. & Seeger MA. X-ray structure of a heterodimeric ABC transporter crystallized in its inward-facing conformation. Chimia (Aarau)66, 802 (2012).

Hohl, M., Briand, C., Grütter, MG. & Seeger, M. Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation. Nat Struct Mol Biol. 19, 395-402 (2012).

Kebbel, F., Kurz, M., Grütter, M. & Stahlberg, H. Projection structure of the secondary citrate/sodium symporter CitSat 6 Angstroem resolution by electron crystallography. J Mol Biol. 418, 117-126 (2012).

Madhurantakam, C., Varadamsetty, G., Grütter, MG., Plückthun, A. & Mittl, PR. Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci. 21, 1015-1028 (2012).

Merz,T., Heck, T. Geueke, B., Mittl, PR., Briand, C., Seebach, D., Kohler, HP. & Grütter, MG. Autoproteolytic and catalytic mechanisms for the beta-aminopeptidase BapA- a member of the Ntn hydrolase family. Structure 20, 1850-1860 (2012).

Mittal, A., Boehm, S., Grütter, MG., Bordignon, E. & Seeger, MA. Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin. J Biol Chemistry 287, 20395-20406 (2012).

Roschitzki-Voser, H., Schröder, T-. Lenherr, ED., Frölich, F., Schweizer, A., Donepudi, M., Ganesan, R., Mittl, PR., Baici, A. & Grütter, MG. Human caspases in vitro: expression, purification and kinetic characterization. Protein Expr Purif. 84, 236-246 (2012).

Seeger, MA., Mittal, A., Velamakanni, S., Hohl, M., Schauer, S., Salaa, I., Grütter, MG. & van Veen, HW. Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders. PLoS One 7(6):e37845 (2012).

Bourquin, F., Capitani, G. & Grütter, MG. PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. Protein Sci. 20, 1492-1508 (2011). 

Devi, VS, & Mittl. PR. Monitoring the disulfide bond formation of a cysteine-rich repeat proteine from Helicobacter pylori in the periplasm of escherichia coli. Curr Microbiol. 62, 903-907 (2011).

Flütsch, A., Schröder, T., Grütter MG. & Patzke, GR. HIV-1 protease inhibition potential of functionalized polyoxometalates. Bioorg. Med. Chem. Lett. 21, 1162-1166 (2011).

Ganesan, R., Jelakovic, S., Mittl, PR., Caflisch, A. & Grütter, MG. In silico identification and crystal structure validation of procaspase-3 inhibitors without a P1 aspartic acid moiety. Acta Crystallogr SectF Struct Biol Cryst Commun. 67(Pt8), 842-850 (2011).

Huwiler, A., Bourquin, F., Kotelevets, N., Pastukhov, O., Capitani, G., Grütter, MG. & Zangemeister-Wittke, U. A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLoS One. 6(8): e22436 (2011). 

Monroe, N., Sennhauser, G., Seeger, M., Briand, C. & Grütter, MG. Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface. J. Struct. Biol. 174, 269-281 (2011).

Pertel, T.,Hausmann, S., Morger, D., Züger, S., Guerra, J., Lascano, J., Reinhard, C., Santoni, FA., Uchil, PD., Chatel, L., Bisiaux, A., Albert, ML., Strambio-De-Castillia, C., Mothes, W., Pizzato, M., Grutter, MG. & Luban, J. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 472, 361-365 (2011). 

Roschitzki, B.,Schauer, S. & Mittl, PR. Recognition of host proteins by Helicobacter cysteine-rich proteine C. Curr Microbiol. 63, 239-249 (2011).

Schärer, MA., Eliot, AC., Grütter, MG. & Capitani, G. Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy . FEBS Lett. 585, 111-114 (2011).

Bourquin, F., Riezman, H., Capitani, G. & Grütter, M. Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure 18, 1054-1065 (2010).

Keller, N., Grütter, MG. & Zerbe, O.Studies of the molecular mechanism of caspase-8 activation by solution NMR. Cell Death Differ. 17, 710-718 (2010).

Kindermann, M., Roschitzki-Voser, H., Caglic, D., Repnik, U., Miniejew, C., Mittl, PR., Kosec, G., Grütter, MG., Turk, B.& Wendt, KU. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 17, 999-1007 (2010).

Kramer, MA., Wetzel, SK:, Plückthun, A., Mittl, PR. & Grütter, MG. Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned c-capping module. J Mol Biol. 404, 381-391 (2010).

Melkko S, Mannocci L, Dumelin CE, Villa A, Sommavilla R, Zhang Y, Grütter MG, Keller N, Jermutus L, Jackson RH, Scheuermann J & Neri D. Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library. Chem Med Chem. 5, 584-590 (2010).

Pham,QT., Bouchard, A., Grütter, MG. & Berthoux, L. Generation of human TRIM5alpha mutants with high HIV-1 restriction acitivity. Gene Ther. 17, 859-871 (2010).

Schärer, MA., Grütter, MG. & Capitani, G. CRK: an evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts. Proteins 78, 2707-2713 (2010).

Schoep,TD., Fulurija, A., Good, F., Lu, W., Hirnbeck, RP., Schwan, C., Choi, SS., Berg, DE., Mittl, PR., Benghezal, M. & Marshall, BJ. Surface properties of Helicobacter pylori urease complex are essential for persistence. PLoS One. 5 (11): e15042 (2010).

Baumgartner, R., Meder, G. , Briand, C., Decock, A., D'arcy, A., Hassiepen, U., Morse, R. & Renatus, M. The crystal structure of caspase-6, a selective effector of axonal degeneration. Biochem. J. 423, 429-439 (2009).

Dumrese, C., Slomianka, L., Ziegler, U., Choi, SS., Kalia, A., Fulurija, A., Lu, W., Berg, DE., Benghezal, M. , Marshall, B. & Mittl, PR. The secreted Heliobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype. FEBS Lett. 583, 1637-1643 (2009).

Gut H, Dominici P, Pilati S, Astegno A, Petoukhov MV, Svergun DI, Grütter MG & Capitani G. A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase. J Mol Biol. 392, 334-351 (2009). 

Keller, N., Mares, J., Zerbe, O. & Grütter, MG. Structural and biochemical studies on procaspase-8: new insights on initiator caspase inactivation. Structure 17, 438-448 (2009).

Neagu, MR., Ziegler, P., Pertel, T., Strambio-De-Castillia, C., Grütter, C., Martinetti, G., Mazzucchelli, L., Grütter, M., Manz, MG. &  Luban, J. Potent inhibition of HIV-1 by TRIM5-cylophilin fusion proteons engineered from human components. J Clin Invest. 119, 3035-3047 (2009).

Schulz BL, Stirnimann CU, Grimshaw JP, Brozzo MS, Fritsch F, Mohorko E, Capitani G, Glockshuber R, Grütter MG & Aebi M. Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc Natl Acad Sci U S A. 106, 11061-11066 (2009).

Sebastian, S., Grütter, C., Strambio de Castillia, C., Pertel, T., Olivari, S., Grütter, M. & Luban, J. An invariant surface patch on the TRIM5(alpha) PRYSPRY domain is required for retroviral restriction but dispensable for capsid-binding. J. Virol. 83, 3365-3373 (2009).

Sennhauser, G., Bukowska, MA., Briand, C. & Grütter, MG. Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa. J Mol Biol 389, 134-145 (2009).

Weinert, C., Grütter, C., Roschitzki-Voser, H., Mittl, PR. & Grütter, M. The crystal structure of human pyrin B30.2 domain: implications for mutations associated with familial mediterranean fever. J Mol Biol. 394, 226-236 (2009).

Eidam, O., Dworkowski, FS., Glockshuber, R., Grütter, MG & Capitani, G. Crystal structure of the ternary FimC-FimF(T)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD. FEBS Lett. 582, 651-655 (2008).

Frey, D., Huber, T., Plückthun, A. & Grütter, MG. Structure of the recombinant antibody Fab fragment f3p4. Acta Crystallogr D Biol Crystallogr. 64, 636-643 (2008).

Grimshaw, JP., Stirnimann, C., Brozzo, MS., Malojcic, G., Grütter, MG., Capitani, G. & Glockshuber, R. DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli. J. Mol. Biol. 18, 667-680 (2008).

Grütter, C., Wilkinson, T., Turner, R., Podichetty, S., Finch, D., Mc Court, M., Loning, S., Jermutus, L. & Grütter, MG. A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions. PNAS USA 105, 20251-20256 (2008).

Hartmann, C., Chami, M., Zachariae, U., de Groot, BL., Engel, A. & Grütter, MG. Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p. J. Mol. Biol. 377, 352-363 (2008).

Merz, T., Wetzel, SK., Firbank, S., Plückthun, A., Grütter, MG. & Mittl, PR. Stabilizing Ionic Interactions in a Full-Consensus Ankyrin Repeat Protein. J.Mol. Biol. 376, 231-240 (2008).

Mukhopadhyay D., Howell, KS., Riezmann, H. & Capitani, G. Sphinganine-1-phosphate lyase: Identifying key residues for function in vivo and in vitro. J Biol Chem. 283, 20159-20169 (2008).

Narzi, D., Siu, SW., Stirnimann, CU., Grimshaw, JP., Glockshuber, R., Capitani, G. & Böckmann, RA. Evidence for proton shuffling in a thioredoxin-like protein during catalysis. J Mol Biol. 382, 978-986 (2008).

Puorger, C., Eidam, O., Capitani, G., Erilov, D., Grütter, M. & Glockshuber, R. Infinite kinetic stability against dissociation of supramolecular protein complexes through donor strand complementation. Structure 16, 631-642 (2008).

Sennhauser, G. & Grütter, M. Chaperone-assisted crystallography with DARPins. Structure 16, 1443-1453 (2008).

Vacca, RA., Giannattasio, S., Capitani, G., Marra, E. & Christen, P. Molecular evolution of B6 enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme. BMC Biochem. 9, 17 (2008).

Göschke, R., Stutz,S., Rasetti V., Cohen, NC., Rahuel , J., Rigollier, P., Baum, HP., Forgiarini, P., Schnell, CR., Wagner, T., Grütter, MG., Fuhrer, W., Schilling, W., Cumin, F., Wood, JM. & Maibaum, J. Novel 2.7-dialkyl-substituted 5 (S) amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin. J. Med.Chem. 50, 4818-4831 (2007).

Maibaum J., Stutz, S., Göschke, R., Rigollier, P., Yamaguchi, Y., Cumin, F., Rahuel, J., Baum, HP., Cohen, NC., Schnell, C., Fuhrer, W., Grütter, M., Schilling, W. & Wood, J. Structural modification of the P2' position of 2,7-dialkyl-substituted 5 (S) amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. J. Med.Chem. 50, 4832-4844 (2007).

Mittl, P.R. & Schneider-Brachert, W. Sel1-like repeat proteins in signal transduction. Cell Signal 19, 20-31 (2007).

Ogura M., Perez, JC., Mittl, PR., Lee, HK., Dailide, G., Tan, S., Ito, Y., Secka, O., Dailidiene, D., Putty, K., Berg, DE. & Kalia, A. Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. PLoS Comput. Biol. 3, e151 (2007).

Papin, S., Cuenin, S., Agostini, L., Martinon, F., Werner, S., Beer, HD., Grütter, C., Grütter, M. & Tschopp J. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 14, 1457-1466 (2007).

Schweizer, A., Roschitzki-Voser, H., Amstutz, P., Briand, C., Gulotti-Georgieva, M., Prenosil, E., Binz, HK., Capitani, G., Baici, A., Plückthun, A. & Grütter MG. Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism. Structure 15, 625-636 (2007).

Sennhauser, G., Amstutz, P., Briand, C., Storchenegger, O., & Grütter, M.G. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PloS Biol . 5, e7 (ePub), (2007).

Binz, H.K., Kohl, A., Plückthun, A. & Grütter M.G. Crystal structure of a consensus-designed ankyrin repeat protein: implications for stability. Proteins 65, 280-284 (2006).

Capitani, G., Eidam, O. & Grütter, M.G. Evidence for a novel domain of bacterial outer membrane ushers. Proteins 65, 816-823 (2006).

Capitani, G., Eidam, O., Glockshuber, R. & Grütter, M.G. Structural and functional insights into the assembly of type 1 pili from Escherichia coli. Microbes Infect. 8, 2284-2290 (2006).

Ekici, O.D., Li, Z.Z., Campbell, A.J., James, K.E., Asgian, J.L., Mikolajczyk, J., Salvesen, G.S., Ganesan, R., Jelakovic, S., Grütter, M.G. & Powers, J.C. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J. Med. Chem. 49, 5728-5749 (2006).

Fasan, R., Dias, RL., Moehle, K., Zerbe, O., Obrecht, D., Mittl, PR., Grütter, MG. & Robinson JA. Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction. Chembiochem. 7, 515-526 (2006).

Frey, D., Braun, O., Briand, C., Vasak, M. & Grütter, M.G. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure 14, 901-911 (2006).

Ganesan, R., Jelakovic, S., Campbell A.J., Li, Z.Z., Asgian, J.L., Powers, J.C. & Grütter, M.G. Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors. Biochemistry 45, 9059-9067 (2006).

Ganesan, R., Mittl, P.R., Jelakovic, S. & Grütter, M.G. Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J. Mol. Biol. 359, 1378-1388 (2006).

Grütter, C., Briand, C., Capitani, G., Mittl, P.R., Papin, S., Tschopp, J. & Grütter, M.G. Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett. 580, 99-106 (2006).

Gut, H., Pennacchietti, E., John, R.A., Bossa, F., Capitani, G., De Biase, D. & Grütter M.G. Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB. EMBO J. 25, 2643-2651 (2006).

Mittl, P.R., & Grütter, M.G. Opportunities for structure-based design of protease -directed drugs. Curr. Opin. Struct. Biol. 16, 769-775 (2006).

Stirnimann C.U., Grütter M.G., Glockshuber R. & Capitani G. nDsbD: a redox interaction hub in the Escherichia coli periplasm. Cell Mol Life Sci. 63, 1642-1648 (2006).

Stirnimann CU,Rozhkova A, Grauschopf U, Böckmann RA, Glockshuber R, Capitani G, Grütter MG. High-resolution Structures of Escherichia coli cDsbD in Different Redox States: A Combined Crystallographic, Biochemical and Computational Study. J Mol Biol. 358, 829-845 (2006).

Tao M, Turk K, Diez J, Grütter MG, Fritz G, Steuber J. Crystallization of the NADH-oxidizing domain of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Acta Cryst. 62, 110-112 (2006).

Yu H., Kohl A., Binz H.K., Plückthun A., Grütter M.G. & van Gunsteren W.F. Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins. Proteins 65, 285-295 (2006).

Amstutz, P., Binz, H.K., Parizek, P., Stumpp, M.T., Kohl, A., Grütter, M.G., Forrer, P. & Plückthun, A. Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins. J Biol Chem. 280, 24715-24722 (2005).

Capitani, G., De Biase, D., Gut, H., Ahmed, S. & Grütter, M.G. Structural model of human GAD65: Prediction and interpretation of biochemical and immunogenic features. Proteins 59, 7-14 (2005).

Capitani, G., Tschopp, M., Eliot, A.C., F., K.J. & Grütter, M.G. Structure of ACC synthase inactivated by the mechanism-based inhibitor l-vinylglycine. FEBS Lett. 579,2458-2462 (2005).

Kohl, A., Amstutz, P., Parizek, P., Binz, H.K., Briand, C., Capitani, G., Forrer, P., Plückthun, A. & Grütter, M.G. Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein. Structure 13, 1131-1141 (2005).

Nishiyama, M., Horst, R., Eidam, O., Herrmann, T., Ignatov, O., Vetsch, M., Bettendorff, P., Jelesarov, I., Grütter, M.G., Wüthrich, K., Glockshuber, R. & Capitani, G. Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD. EMBO J. 24, 2075-2086 (2005).

Stirnimann, C.U., Rozhkova, A., Grauschopf, U., Grütter, M.G., Glockshuber, R. & Capitani, G. Structural basis and kinetics of DsbD-dependent cytochrome c maturation. Structure 13, 985-993 (2005).

Binz, H.K., Amstutz, P., Kohl, A., Stumpp, M.T., Briand, C., Forrer, P., Grütter, M.G. & Plückthun, A. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat. Biotechnol. 22, 575-82 (2004).

Capitani, G. & Schurmann, P. On the quaternary assembly of spinach chloroplast thioredoxin m. Photosynth. Res. 79, 281-85 (2004).

Deriu, D., Gassmann, M., Firbank, S., Ristig, D., Lampert, C., Mosbacher, J., Froestl, W., Kaupmann, K., Bettler, B. & Grütter, M.G. Determination of the minimal functional ligand binding domain of the GABA B (1b) receptor. Biochem. J. 386, 423-31 (2004).

Lüthy, L., Grütter, M.G. & Mittl, P.R. The crystal structure of Helicobacter cysteine-rich protein C at 2.0 A resolution: similar peptide-binding sites in TPR and SEL1-like repeat proteins. J. Mol. Biol. 340, 829-41 (2004).

Rozhkova, A., Stirnimann, C.U., Frei, P., Grauschopf, U., Brunisholz, R., Grütter, M.G., Capitani, G. & Glockshuber, R. Structural basis and kinetics of inter- and intramolecular disulfide exchange in the redox catalyst DsbD. EMBO J. 23, 1709-19 (2004).

Capitani, G., Tramonti, A., Bossa, F., Grütter, M.G. & De Biase, D. The critical structural role of a highly conserved histidine residue in group II amino acid decarboxylases. FEBS Lett. 554, 41-4 (2003).

Capitani, G., De Biase, D., Aurizi, C., Gut, H., Bossa, F. & Grütter, M.G. Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase. EMBO J. 22, 4027-37 (2003).

Capitani, G., Eliot, A.C., Gut, H., Khomutov, R.M., Kirsch, J.F. & Grütter, M.G. Structure of 1-aminocyclopropane-1-carboxylate synthase in complex with an amino-oxy analogue of the substrate: implications for substrate binding. Biochim. Biophys. Acta, 11 (2003).

Ciatto, C., Capitani, G., Tissot, A.C., Pecorari, F., Plückthun, A. & Grütter, M.G. Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db. FEBS Lett. 543, 11-5 (2003).

Cowan-Jacob, S.W., Kaufmann, M., Anselmo, A.N., Stark, W. & Grütter, M.G. Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr. D 59, 2218-27 (2003).

Deriu, D., Briand, C., Mistiniene, E., Naktinis, V. & Grütter, M.G. Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Acta Crystallogr. D 59, 1676-8 (2003).

Donepudi, M., Mac Sweeney, A., Briand, C. & Grütter, M.G. Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell. 11, 543-9 (2003).

Hiller, S., Kohl, A., Fiorito, F., Herrmann, T., Wider, G., Tschopp, J., Grütter, M.G. & Wüthrich, K. NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.[see comment]. Structure 11, 1199-205 (2003).

Kohl, A., Binz, H.K., Forrer, P., Stumpp, M.T., Plückthun, A. & Grütter, M.G. Designed to be stable: crystal structure of a consensus ankyrin repeat protein. PNAS U.S.A. 100, 1700-5 (2003).

Schweizer, A., Briand, C. & Grütter, M.G. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J. Biol. Chem. 278, 42441-7 (2003).

Wood, J.M., Maibaum, J., Rahuel, J., Grütter, M.G., Cohen, N.C., Rasetti, V., Ruger, H., Goschke, R., Stutz, S., Fuhrer, W., Schilling, W., Rigollier, P., Yamaguchi, Y., Cumin, F., Baum, H.P., Schnell, C.R., Herold, P., Mah, R., Jensen, C., O'Brien, E., Stanton, A. & Bedigian, M.P. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem. Biophys. Res. Commun. 308, 698-705 (2003).

Capitani, G., McCarthy, D.L., Gut, H., Grütter, M.G. & Kirsch, J.F. Apple 1-aminocyclopropane-1-carboxylate synthase in complex with the inhibitor L-aminoethoxyvinylglycine. Evidence for a ketimine intermediate. J. Biol. Chem. 277, 49735-42 (2002).

Daubenberger, C.A., Nickel, B., Ciatto, C., Grütter, M.G., Poltl-Frank, F., Rossi, L., Siegler, U., Robinson, J., Kashala, O., Patarroyo, M.E. & Pluschke, G. Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of Plasmodium falciparum merozoite surface protein 1 displaying dimorphic amino acid polymorphism are highly constrained. Eur. J. Immunol. 32, 3667-77 (2002).

Donepudi, M. & Grütter, M.G. Structure and zymogen activation of caspases. Biophys. Chem. 102, 145-53 (2002).

Fluckiger, S., Mittl, P.R., Scapozza, L., Fijten, H., Folkers, G., Grütter, M.G., Blaser, K. & Crameri, R. Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution. J. Immunol. 168, 1267-72 (2002).

Fritz, G., Mittl, P.R., Vasak, M., Grütter, M.G. & Heizmann, C.W. The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution. J. Biol. Chem. 277, 33092-8 (2002).

Kaufmann, M., Bozic, D., Briand, C., Bodmer, J.L., Zerbe, O., Kohl, A., Tschopp, J. & Grütter, M.G. Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett. 527, 250-4 (2002).

Kaufmann, M., Lindner, P., Honegger, A., Blank, K., Tschopp, M., Capitani, G., Plückthun, A. & Grütter, M.G. Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen. J. Mol. Biol. 318, 135-47 (2002).

Lüthy, L., Grütter, M.G. & Mittl, P.R. The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein. J. Biol. Chem. 277, 10187-93 (2002).

Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D.W., Briand, C. & Grütter, M.G. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277, 45162-71 (2002).

Mittl, P.R., Fritz, G., Sargent, D.F., Richmond, T.J., Heizmann, C.W. & Grütter, M.G. Metal-free MIRAS phasing: structure of apo-S100A3. Acta Crystallogr. D 58, 1255-61 (2002).