Publications of the Dutzler Group

ZORA Publication List

Publications

• 2020

  • Quesada, R., & Dutzler, R. (2020). Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis Journal of Cystic Fibrosis, 19 Suppl, S37–S41. https://doi.org/10.1016/j.jcf.2019.10.020

• 2019

  • Manatschal, C., Pujol-Giménez, J., Poirier, M., Reymond, J.-L., Hediger, M. A., & Dutzler, R. (2019). Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds ELife, 8, e51913. https://doi.org/10.7554/eLife.51913
  • Walter, J. D., Sawicka, M., & Dutzler, R. (2019). Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport ELife, 8, e46986. https://doi.org/10.7554/eLife.46986
  • Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G. T., Dutzler, R., & Paulino, C. (2019). Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM ELife, 8, e44364. https://doi.org/10.7554/eLife.44364
  • Alvadia, C., Lim, N. K., Clerico Mosina, V., Oostergetel, G. T., Dutzler, R., & Paulino, C. (2019). Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F ELife, 8, e44365. https://doi.org/10.7554/eLife.44365

• 2018

  • Lam, A. K. M., & Dutzler, R. (2018). Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A ELife, 7, 39122. https://doi.org/10.7554/eLife.39122
  • Deneka, D., Sawicka, M., Lam, A. K. M., Paulino, C., & Dutzler, R. (2018). Structure of a volume-regulated anion channel of the LRRC8 family Nature, 558, 254–259. https://doi.org/10.1038/s41586-018-0134-y

• 2017

  • Paulino, C., Kalienkova, V., Lam, A. K. M., Neldner, Y., & Dutzler, R. (2017). Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM Nature, 552, 421–425. https://doi.org/10.1038/nature24652
  • Schenck, S., Kunz, L., Sahlender, D., Pardon, E., Geertsma, E. R., Savtchouk, I., Suzuki, T., Neldner, Y., Štefanić, S., Steyaert, J., Volterra, A., & Dutzler, R. (2017). Generation and characterization of Anti-VGLUT nanobodies acting as inhibitors of transport Biochemistry, 56, 3962–3971. https://doi.org/10.1021/acs.biochem.7b00436
  • Paulino, C., Neldner, Y., Lam, A. K. M., Kalienkova, V., Brunner, J. D., Schenck, S., & Dutzler, R. (2017). Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A ELife, 6, 26232. https://doi.org/10.7554/eLife.26232
  • Ehrnstorfer, I. A., Manatschal, C., Arnold, F. M., Laederach, J., & Dutzler, R. (2017). Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family Nature Communications, 8, 14033. https://doi.org/10.1038/ncomms14033

• 2016

  • Brunner, J. D., Schenck, S., & Dutzler, R. (2016). Structural basis for phospholipid scrambling in the TMEM16 family Current Opinion in Structural Biology, 39, 61–70. https://doi.org/10.1016/j.sbi.2016.05.020
  • Geertsma, E. R., Chang, Y.-N., Shaik, F. R., Neldner, Y., Pardon, E., Steyaert, J., & Dutzler, R. (2016). Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family Nature Structural & Molecular Biology, 23, 462. https://doi.org/10.1038/nsmb0516-462
  • Bertozzi, C., Zimmermann, I., Engeler, S., Hilf, R. J. C., & Dutzler, R. (2016). Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels PLoS Biology, 14, e1002393. https://doi.org/10.1371/journal.pbio.1002393
  • Lim, N. K., Lam, A. K. M., & Dutzler, R. (2016). Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A Journal of General Physiology, 148, 375–392. https://doi.org/10.1085/jgp.201611650

• 2015

  • Geertsma, E. R., Chang, Y.-N., Shaik, F. R., Neldner, Y., Pardon, E., Steyaert, J., & Dutzler, R. (2015). Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family Nature Structural & Molecular Biology, 22, 803–808. https://doi.org/10.1038/nsmb.3091

• 2014

  • Brunner, J. D., Lim, N. K., Schenck, S., Duerst, A., & Dutzler, R. (2014). X-ray structure of a calcium-activated TMEM16 lipid scramblase Nature, 516, 207–212. https://doi.org/10.1038/nature13984
  • Ehrnstorfer, I. A., Geertsma, E. R., Pardon, E., Steyaert, J., & Dutzler, R. (2014). Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport Nature Structural & Molecular Biology, 21, 990–996. https://doi.org/10.1038/nsmb.2904

• 2013

  • Garcia-Celma, J., Szydelko, A., & Dutzler, R. (2013). Functional characterization of a ClC transporter by solid-supported membrane electrophysiology Journal of General Physiology, 141, 479–491. https://doi.org/10.1085/jgp.201210927

• 2012

  • Zimmermann, I., Marabelli, A., Bertozzi, C., Sivilotti, L. G., & Dutzler, R. (2012). Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations PLoS Biology, 10, e1001429. https://doi.org/10.1371/journal.pbio.1001429

Pagination