Publications of the Dutzler Group

ZORA Publication List

Publications

• 2025

  • Arndt, M., Schweri, A., & Dutzler, R. (2025). Structural basis for lipid transport at membrane contact sites by the IST2-OSH6 complex Nature Structural & Molecular Biology, online. https://doi.org/10.1038/s41594-025-01660-z
  • Sukalskaia, Anastasiia; Karner, Andreas; Pugnetti, Anna; Weber, Florian; Plochberger, Birgit; Dutzler, Raimund (2025). Interactions between TTYH2 and APOE facilitate endosomal lipid transfer Nature, 644(8075):273-279.
  • Liziczai, Márton; Fuchs, Ariane; Manatschal, Cristina; Dutzler, Raimund (2025). Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1 Nature Communications, 16(1):761.

• 2024

  • Quinodoz, Mathieu; Rutz, Sonja; Peter, Virginie; Garavelli, Livia; Innes, A Micheil; Lehmann, Elena F; Kellenberger, Stephan; Peng, Zhong; Barone, Angelica; Campos-Xavier, Belinda; Unger, Sheila; Rivolta, Carlo; Dutzler, Raimund; Superti-Furga, Andrea (2024). De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder The EMBO Journal, 44(2):413-436.
  • Drożdżyk, Katarzyna; Peter, Martina; Dutzler, Raimund (2024). Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs eLife, 13:RP96138.

• 2023

  • Lam, Andy Km; Dutzler, Raimund (2023). Mechanistic basis of ligand efficacy in the calcium-activated chloride channel TMEM16A The EMBO Journal, 42(24):e115030.
  • Tippett, David N; Breen, Colum; Butler, Stephen J; Sawicka, Marta; Dutzler, Raimund (2023). Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange eLife, 12:RP87178.
  • Ramanadane, Karthik; Liziczai, Márton; Markovic, Dragana; Straub, Monique S; Rosalen, Gian T; Udovcic, Anto; Dutzler, Raimund; Manatschal, Cristina (2023). Structural and functional properties of a plant NRAMP-related aluminum transporter eLife, 12:e85641.
  • Lehmann, Elena Farah; Liziczai, Márton; Drożdżyk, Katarzyna; Altermatt, Patrick; Langini, Cassiano; Manolova, Vania; Sundstrom, Hanna; Dürrenberger, Franz; Dutzler, Raimund; Manatschal, Cristina (2023). Structures of ferroportin in complex with its specific inhibitor vamifeport eLife, 12:e83053.
  • Rutz, Sonja; Deneka, Dawid; Dittmann, Antje; Sawicka, Marta; Dutzler, Raimund (2023). Structure of a volume-regulated heteromeric LRRC8A/C channel Nature Structural & Molecular Biology, 30(1):52-61.

• 2022

  • Arndt, Melanie; Alvadia, Carolina; Straub, Monique S; Clerico Mosina, Vanessa; Paulino, Cristina; Dutzler, Raimund (2022). Structural basis for the activation of the lipid scramblase TMEM16F Nature Communications, 13(1):6692.
  • Sawicka, Marta; Dutzler, Raimund (2022). Regulators of cell volume: The structural and functional properties of anion channels of the LRRC8 family Current Opinion in Structural Biology, 74:102382.
  • Lam, Andy K M; Rutz, Sonja; Dutzler, Raimund (2022). Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC Nature Communications, 13:2798.
  • Ramanadane, Karthik; Straub, Monique S; Dutzler, Raimund; Manatschal, Cristina (2022). Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family eLife, 11:e74589.

• 2021

  • Deneka, Dawid; Rutz, Sonja; Hutter, Cedric A J; Seeger, Markus A; Sawicka, Marta; Dutzler, Raimund (2021). Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains Nature Communications, 12:5435.
  • Sukalskaia, Anastasiia; Straub, Monique S; Deneka, Dawid; Sawicka, Marta; Dutzler, Raimund (2021). Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions Nature Communications, 12:4893.
  • Straub, Monique S; Alvadia, Carolina; Sawicka, Marta; Dutzler, Raimund (2021). Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling eLife, 10:e69800.
  • Lam, Andy K M; Dutzler, Raimund (2021). Mechanism of pore opening in the calcium-activated chloride channel TMEM16A Nature Communications, 12:786.
  • Lam, Andy K M; Rheinberger, Jan; Paulino, Cristina; Dutzler, Raimund (2021). Gating the pore of the calcium-activated chloride channel TMEM16A Nature Communications, 12:785.

• 2020

  • Drożdżyk, Katarzyna; Sawicka, Marta; Bahamonde-Santos, Maria-Isabel; Jonas, Zaugg; Deneka, Dawid; Albrecht, Christiane; Dutzler, Raimund (2020). Cryo-EM structures and functional properties of CALHM channels of the human placenta eLife, 9:e55853.

Pagination