Publications of the Jinek Group

ZORA Publication List

Publications

• 2023

  • Zhao, L., Koseki, S. R. T., Silverstein, R. A., Amrani, N., Peng, C., Kramme, C., Savic, N., Pacesa, M., Rodríguez, T. C., Stan, T., Tysinger, E., Hong, L., Yudistyra, V., Ponnapati, M. R., Jacobson, J. M., Church, G. M., Jakimo, N., Truant, R., Jinek, M., … Chatterjee, P. (2023). PAM-flexible genome editing with an engineered chimeric Cas9 Nature Communications, 14, 6175. https://doi.org/10.1038/s41467-023-41829-y

• 2022

  • Schmitz, M., Querques, I., Oberli, S., Chanez, C., & Jinek, M. (2022). Structural basis for the assembly of the type V CRISPR-associated transposon complex Cell, 185, 4999-5010.e17. https://doi.org/10.1016/j.cell.2022.11.009
  • Pacesa, M., Lin, C.-H., Cléry, A., Saha, A., Arantes, P. R., Bargsten, K., Irby, M. J., Allain, F. H.-T., Palermo, G., Cameron, P., Donohoue, P. D., & Jinek, M. (2022). Structural basis for Cas9 off-target activity Cell, 185, 4067-4081.e21. https://doi.org/10.1016/j.cell.2022.09.026
  • Nierzwicki, Ł., East, K. W., Binz, J. M., Hsu, R. V., Ahsan, M., Arantes, P. R., Skeens, E., Pacesa, M., Jinek, M., Lisi, G. P., & Palermo, G. (2022). Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR-Cas9 Nature Catalysis, 5, 912–922. https://doi.org/10.1038/s41929-022-00848-6
  • Muckenfuss, L. M., Migenda Herranz, A. C., Boneberg, F. M., Clerici, M., & Jinek, M. (2022). Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3’ end biogenesis. ELife, 11, e80332. https://doi.org/10.7554/eLife.80332
  • Pacesa, M., Loeff, L., Querques, I., Muckenfuss, L. M., Sawicka, M., & Jinek, M. (2022). R-loop formation and conformational activation mechanisms of Cas9 Nature, 609, 191–196. https://doi.org/10.1038/s41586-022-05114-0

• 2021

  • Kroupova, A., Ackle, F., Asanović, I., Weitzer, S., Boneberg, F. M., Faini, M., Leitner, A., Chui, A., Aebersold, R., Martinez, J., & Jinek, M. (2021). Molecular architecture of the human tRNA ligase complex ELife, 10, e71656. https://doi.org/10.7554/eLife.71656
  • Querques, I., Schmitz, M., Oberli, S., Chanez, C., & Jinek, M. (2021). Target site selection and remodelling by type V CRISPR-transposon systems Nature, 599, 497–502. https://doi.org/10.1038/s41586-021-04030-z
  • Makasheva, K., Bryan, L. C., Anders, C., Panikulam, S., Jinek, M., & Fierz, B. (2021). Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor Journal of the American Chemical Society, 143, 16313–16319. https://doi.org/10.1021/jacs.1c06195
  • Donohoue, P. D., Pacesa, M., Lau, E., Vidal, B., Irby, M. J., Nyer, D. B., Rotstein, T., Banh, L., Toh, M. S., Gibson, J., Kohrs, B., Baek, K., Owen, A. L. G., Slorach, E. M., van Overbeek, M., Fuller, C. K., May, A. P., Jinek, M., & Cameron, P. (2021). Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells Molecular Cell, 81, 3637-3649.e5. https://doi.org/10.1016/j.molcel.2021.07.035
  • Rothgangl, T., Dennis, M. K., Lin, P. J. C., Oka, R., Witzigmann, D., Villiger, L., Qi, W., Hruzova, M., Kissling, L., Lenggenhager, D., Borrelli, C., Egli, S., Frey, N., Bakker, N., Walker, J. A., Kadina, A. P., Victorov, D. V., Pacesa, M., Kreutzer, S., … Schwank, G. (2021). In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels Nature Biotechnology, 39, 949–957. https://doi.org/10.1038/s41587-021-00933-4
  • Bawankar, P., Lence, T., Paolantoni, C., Haussmann, I. U., Kazlauskiene, M., Jacob, D., Heidelberger, J. B., Richter, F. M., Nallasivan, M. P., Morin, V., Kreim, N., Beli, P., Helm, M., Jinek, M., Soller, M., & Roignant, J.-Y. (2021). Hakai is required for stabilization of core components of the m6A mRNA methylation machinery Nature Communications, 12, 3778. https://doi.org/10.1038/s41467-021-23892-5
  • Asanović, I., Strandback, E., Kroupova, A., et al, & Jinek, M. (2021). The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response Molecular Cell, 81, 2520-2532.e16. https://doi.org/10.1016/j.molcel.2021.04.007

• 2020

  • Saha, A., Arantes, P. R., Hsu, R. V., Narkhede, Y. B., Jinek, M., & Palermo, G. (2020). Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a Journal of Chemical Information and Modeling, 60, 6427–6437. https://doi.org/10.1021/acs.jcim.0c00929
  • Casalino, L., Nierzwicki, Ł., Jinek, M., & Palermo, G. (2020). Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics ACS Catalysis, 10, 13596–13605. https://doi.org/10.1021/acscatal.0c03566
  • Pinto, P. H., Kroupova, A., Schleiffer, A., Mechtler, K., Jinek, M., Weitzer, S., & Martinez, J. (2020). ANGEL2 is a member of the CCR4 family of deadenylases with 2’,3’-cyclic phosphatase activity. Science, 369, 524–530. https://doi.org/10.1126/science.aba9763
  • Wrona, D., Pastukhov, O., Pritchard, R. S., Raimondi, F., Tchinda, J., Jinek, M., Siler, U., & Reichenbach, J. (2020). CRISPR-Directed Therapeutic Correction at the NCF1 Locus Is Challenged by Frequent Incidence of Chromosomal Deletions Molecular Therapy - Methods & Clinical Development, 17, 936–943. https://doi.org/10.1016/j.omtm.2020.04.015
  • Davies, K., & Jínek, M. (2020). The CRISPR-RNA World: An Interview with Martin Jínek The CRISPR Journal, 3, 68–72. https://doi.org/10.1089/crispr.2020.29091.mji
  • Garcia-Doval, C., Schwede, F., Berk, C., Rostøl, J. T., Niewoehner, O., Tejero, O., Hall, J., Marraffini, L. A., & Jinek, M. (2020). Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6 Nature Communications, 11, 1596. https://doi.org/10.1038/s41467-020-15334-5

• 2019

  • Jinek, M. (2019). Uncut but primed for change The CRISPR Journal, 2, 352–354. https://doi.org/10.1089/crispr.2019.29079.mji

Pagination