Publications of the Plückthun Group

ZORA Publication List

Publications

• 2025

  • Kolibius, J., Weiss, F., Freitag, P., & Plückthun, A. (2025). Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced payload expression Molecular Therapy - Methods & Clinical Development, 33(4), 101582. https://doi.org/10.1016/j.omtm.2025.101582
  • Umbaugh, C. S., Groth, M., Erkut, C., Lee, K.-S., Marinho, J., Linder, S., Iser, F., Kapp, J. N., Schroeter, P., Dolaner, S., Kayserili, A., Helm, D., Schneider, M., Hartmann, J., Walch, P., Barth, T. F. E., Mellert, K., Dreier, B., Schaefer, J. V., … Scholl, C. (2025). Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma Science Advances, 11, eadu2796. https://doi.org/10.1126/sciadv.adu2796
  • Nakadate, M., Kojima, R., Seike, N., Tachibana, R., Fujita, K., Tsuchiya, R., Kamiya, M., Plückthun, A., & Urano, Y. (2025). Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids Journal of the American Chemical Society, 147, 30684–30693. https://doi.org/10.1021/jacs.5c04193
  • Vacca, S., Gragera, M., Buschiazzo, A., Herreros, D., Krieger, J. M., Bonn-Garcia, S., Melero, R., Sorzano, C. O., Carazo, J. M., Medalia, O., & Plückthun, A. (2025). Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation Science Advances, 11, eadu9945. https://doi.org/10.1126/sciadv.adu9945
  • Winkelvoß, Dorothea; Vukovic, David; Hänny, Anna-Carina; Riermeier, Luca; Udovcic, Anto; Kolibius, Jonas; Honegger, Annemarie; Mittl, Peer R E; Michel, Erich; Hansen, Simon; Plückthun, Andreas (2025). Molecular features defining the efficiency of bioPROTACs Communications Biology, 8(1):946.
  • Weiss, Fabian; Kolibius, Jonas; Freitag, Patrick C; Gantenbein, Felix; Kipar, Anja; Plückthun, Andreas (2025). Dendritic cell targeting in lymph nodes with modular adapters boosts HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21 Molecular therapy. Oncology, 33(2):200984.
  • Kapp, Jonas N; Verdurmen, Wouter P R; Schaefer, Jonas V; Kopra, Kari; Nagy-Davidescu, Gabriela; Richard, Elodie; Nokin, Marie-Julie; Ernst, Patrick; Tamaskovic, Rastislav; Schwill, Martin; Degen, Ralph; Scholl, Claudia; Santamaría, David; Plückthun, Andreas (2025). A nucleotide-independent, pan-RAS-targeted DARPin elicits anti-tumor activity in a multimodal manner Molecular Oncology:Epub ahead of print.
  • Zinsli, Léa V; Sobieraj, Anna M; Du, Jiemin; Ernst, Patrick; Meile, Susanne; Kilcher, Samuel; Iseli, Cedric; Keller, Anja P; Dreier, Birgit; Mittl, Peer R E; Plückthun, Andreas; Loessner, Martin J; Schmelcher, Mathias; Dunne, Matthew (2025). Heterodimerization of staphylococcal phage φ2638A endolysin isoforms and their functional role in bacterial lysis microLife, 6:uqaf011.
  • Sequeira, Daniela Policarpo; Suomalainen, Maarit; Freitag, Patrick C; Plückthun, Andreas; Klingenbrunner, Michael; Fischer, Lucy; Hemmi, Silvio; Münz, Christian; Volle, Romain; Greber, Urs F (2025). Activated blood-derived human primary T cells support replication of HAdV C5 and virus transmission to polarized human primary epithelial cells Journal of Virology, 99(5):e0182524.
  • Münick, Philipp; Strubel, Alexander; Balourdas, Dimitrios-Ilias; Funk, Julianne S; Mernberger, Marco; Osterburg, Christian; Dreier, Birgit; Schaefer, Jonas V; Tuppi, Marcel; Yüksel, Büşra; Schäfer, Birgit; Knapp, Stefan; Plückthun, Andreas; Stiewe, Thorsten; Joerger, Andreas C; Dötsch, Volker (2025). DARPin-induced reactivation of p53 in HPV-positive cells Nature Structural & Molecular Biology, 32(5):790-801.
  • Tröster, Vera; Wong, Ronald P; Börgel, Arne; Cakilkaya, Baris; Renz, Christian; Möckel, Martin M; Eifler-Olivi, Karolin; Marinho, Joana; Reinberg, Thomas; Furler, Sven; Schaefer, Jonas V; Plückthun, Andreas; Wolf, Eva; Ulrich, Helle D (2025). Custom affinity probes reveal DNA-damage-induced, ssDNA-independent chromatin SUMOylation in budding yeast Cell Reports, 44(3):115353.

• 2024

  • Münick, Philipp; Zielinski, Jasmin; Strubel, Alexander; Gutfreund, Niklas; Dreier, Birgit; Schaefer, Jonas V; Schäfer, Birgit; Gebel, Jakob; Osterburg, Christian; Chaikuad, Apirat; Knapp, Stefan; Plückthun, Andreas; Dötsch, Volker (2024). DARPins as a novel tool to detect and degrade p73 Cell Death and Disease, 15(12):909.
  • Henkin, Gil; Brito, Cláudia; Plückthun, Andreas; Surrey, Thomas (2024). Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin Bio-protocol, 14(22):e5109.
  • Vukovic, David; Winkelvoss, Dorothea; Kapp, Jonas N; Hänny, Anna-Carina; Bürgisser, Héloïse; Riermeier, Luca; Udovcic, Anto; Tiefenboeck, Peter; Plückthun, Andreas (2024). Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy Scientific Reports, 14(1):27153.
  • Mahran, Randa; Kapp, Jonas N; Valtonen, Salla; Champagne, Allison; Ning, Jinying; Gillette, William; Stephen, Andrew G; Hao, Feng; Plückthun, Andreas; Härmä, Harri; Pantsar, Tatu; Kopra, Kari (2024). Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96 ACS Chemical Biology, 19(10):2152-2164.
  • Zhou, Zhiwei; Nguyen, Tra Ly; Li, Xingxiao; Poujol, Christel; Berlinska, Ewa; Michelina, Sandra Vietti; Kapp, Jonas N; Plückthun, Andreas; Winslow, Monte M; Ambrogio, Chiara; Shan, Yibing; Santamaría, David; Westover, Kenneth D (2024). Experimental variables determine the outcome of RAS-RAS interactions Journal of Biological Chemistry, 300(11):107859.
  • Freitag, Patrick C; Kolibius, Jonas; Wieboldt, Ronja; Weber, Remi; Hartmann, K Patricia; van Gogh, Merel; Brücher, Dominik; Läubli, Heinz; Plückthun, Andreas (2024). DARPin-fused T cell engager for adenovirus-mediated cancer therapy. Molecular therapy. Oncology, 32(3):200821.
  • Auger, Shelby A; Venkatachalapathy, Sneha; Suazo, Kiall Francis G; Wang, Yiao; Sarkis, Alexander W; Bernhagen, Kaitlyn; Justyna, Katarzyna; Schaefer, Jonas V; Wollack, James W; Plückthun, Andreas; Li, Ling; Distefano, Mark D (2024). Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry Bioconjugate Chemistry, 35(7):922-933.
  • Stark, Yvonne; Menard, Faye; Jeliazkov, Jeliazko R; Ernst, Patrick; Chembath, Anupama; Ashraf, Mohammed; Hine, Anna V; Plückthun, Andreas (2024). Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules Proceedings of the National Academy of Sciences of the United States of America, 121(27):e2318198121.
  • Dederer, Verena; Sanz Murillo, Marta; Karasmanis, Eva P; Hatch, Kathryn S; Chatterjee, Deep; Preuss, Franziska; Abdul Azeez, Kamal R; Nguyen, Landon Vu; Galicia, Christian; Dreier, Birgit; Plückthun, Andreas; Versees, Wim; Mathea, Sebastian; Leschziner, Andres E; Reck-Peterson, Samara L; Knapp, Stefan (2024). A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2 Journal of Biological Chemistry, 300(7):107469.

Pagination