Publications of the Plückthun Group

ZORA Publication List

Publications

• 2023

  • Leka, Oneda; Wu, Yufan; Zanetti, Giulia; Furler, Sven; Reinberg, Thomas; Marinho, Joana; Schaefer, Jonas V; Plückthun, Andreas; Li, Xiaodan; Pirazzini, Marco; Kammerer, Richard A (2023). A DARPin promotes faster onset of botulinum neurotoxin A1 action. Nature Communications, 14(1):8317.
  • Cucuzza, Stefano; Sitnik, Malgorzata; Jurt, Simon; Michel, Erich; Dai, Wenzhao; Müntener, Thomas; Ernst, Patrick; Häussinger, Daniel; Plückthun, Andreas; Zerbe, Oliver (2023). Unexpected dynamics in femtomolar complexes of binding proteins with peptides. Nature Communications, 14(1):7823.
  • Baumann, Christian; Chiang, Wan‐Chin; Valsecchi, Renato; Jurt, Simon; Deluigi, Mattia; Schuster, Matthias; Rosengren, Karl Johan; Plückthun, Andreas; Zerbe, Oliver (2023). Side‐chain dynamics of the α$_{1B}$ ‐adrenergic receptor determined by NMR via methyl relaxation. Protein Science, 32(11):e4801.
  • Strubel, Alexander; Münick, Philipp; Hartmann, Oliver; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas V; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schäfer, Birgit; Buck, Viktoria; Rosenfeldt, Mathias; Knapp, Stefan; Plückthun, Andreas; Diefenbacher, Markus E; Dötsch, Volker (2023). DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell Death and Disease, 14(10):674.
  • Hartmann, K Patricia; van Gogh, Merel; Freitag, Patrick C; Kast, Florian; Nagy-Davidescu, Gabriela; Borsig, Lubor; Plückthun, Andreas (2023). FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment. Molecular Therapy, 31(10):2914-2928.
  • Maliqi, Liridona; Friedrich, Nikolas; Glögl, Matthias; Schmutz, Stefan; Schmidt, Daniel; Rusert, Peter; Schanz, Merle; Zaheri, Maryam; Pasin, Chloé; Niklaus, Cyrille; Foulkes, Caio; Reinberg, Thomas; Dreier, Birgit; Abela, Irene; Peterhoff, David; Hauser, Alexandra; Kouyos, Roger D; Günthard, Huldrych F; van Gils, Marit J; Sanders, Rogier W; Wagner, Ralf; Plückthun, Andreas; Trkola, Alexandra (2023). Assessing immunogenicity barriers of the HIV-1 envelope trimer. npj vaccines, 8(1):148.
  • Glögl, Matthias; Friedrich, Nikolas; Cerutti, Gabriele; Lemmin, Thomas; Kwon, Young D; Gorman, Jason; Maliqi, Liridona; Mittl, Peer R E; Hesselman, Maria C; Schmidt, Daniel; Weber, Jacqueline; Foulkes, Caio; Dingens, Adam S; Bylund, Tatsiana; Olia, Adam S; Verardi, Raffaello; Reinberg, Thomas; Baumann, Nicolas S; Rusert, Peter; Dreier, Birgit; Shapiro, Lawrence; Kwong, Peter D; Plückthun, Andreas; Trkola, Alexandra (2023). Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nature Structural & Molecular Biology, 30(9):1323-1336.
  • Shi, Jie; Hauschulte, Kristine; Mikicic, Ivan; Maharjan, Srijana; Arz, Valerie; Strauch, Tina; Heidelberger, Jan B; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Beli, Petra; Ulrich, Helle D; Wollscheid, Hans-Peter (2023). Nuclear myosin VI maintains replication fork stability. Nature Communications, 14(1):3787.
  • Freitag, Patrick C; Kaulfuss, Meike; Flühler, Lea; Mietz, Juliane; Weiss, Fabian; Brücher, Dominik; Kolibius, Jonas; Hartmann, K Patricia; Smith, Sheena N; Münz, Christian; Chijioke, Obinna; Plückthun, Andreas (2023). Targeted adenovirus-mediated transduction of human T cells in vitro and in vivo. Molecular Therapy - Methods & Clinical Development, 29:120-132.
  • Gut, Melanie; Dreier, Birgit; Furler, Sven; Sobek, Jens; Plückthun, Andreas; Holland, Jason P (2023). Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo. RSC Chemical Biology, 4(7):494-505.
  • Becker, Lukas; Plückthun, Andreas (2023). DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin. Scientific Reports, 13(1):8048.
  • Blanc, Marine; Lettl, Clara; Guérin, Jérémy; Vieille, Anaïs; Furler, Sven; Briand-Schumacher, Sylvie; Dreier, Birgit; Bergé, Célia; Plückthun, Andreas; Vadon-Le Goff, Sandrine; Fronzes, Rémi; Rousselle, Patricia; Fischer, Wolfgang; Terradot, Laurent (2023). Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS Pathogens, 19(5):e1011368.
  • Schubert, Rajib; Bae, Taegeun; Simic, Branko; Smith, Sheena N; Park, Seong-Ho; Nagy-Davidescu, Gabriela; Gradinaru, Viviana; Plückthun, Andreas; Hur, Junho K (2023). CRISPR-clear imaging of melanin-rich B16-derived solid tumors. Communications Biology, 6(1):370.
  • Klenk, Christoph; Scrivens, Maria; Niederer, Anina; Shi, Shuying; Mueller, Loretta; Gersz, Elaine; Zauderer, Maurice; Smith, Ernest S; Strohner, Ralf; Plückthun, Andreas (2023). A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. Nature Communications, 14(1):1770.
  • Schellhorn, Sebastian; Brücher, Dominik; Wolff, Natascha A; Schröer, Katrin; Sallard, Erwan; Mese, Kemal; Zhang, Wenli; Ehrke-Schulz, Eric; Thévenod, Frank; Plückthun, Andreas; Ehrhardt, Anja (2023). Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein. Human Gene Therapy, 34(5-6):203-216.
  • Michel, Erich; Cucuzza, Stefano; Mittl, Peer R E; Zerbe, Oliver; Plückthun, Andreas (2023). Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry, 62(2):318-329.

• 2022

  • Strubel, Alexander; Münick, Philipp; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schäfer, Birgit; Knapp, Stefan; Plückthun, Andreas; Dötsch, Volker (2022). Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death and Differentiation, 29(12):2445-2458.
  • Kiss, Cedric; Gall, Flavio M; Dreier, Birgit; Adams, Michael; Riedl, Rainer; Plückthun, Andreas; Mittl, Peer R E (2022). Structure of a hydrophobic leucinostatin derivative determined by host lattice display. Acta Crystallographica. Section D: Structural Biology, 78(Pt 12):1439-1450.
  • Philippi, Michael; Richter, Christian P; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspötter, Michael; Kurre, Rainer; Holthuis, Joost C M; Garcia, K Christopher; Plückthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang (2022). Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets. Small, 18(50):2203723.
  • Campbell, Benjamin F N; Dittmann, Antje; Dreier, Birgit; Plückthun, Andreas; Tyagarajan, Shiva K (2022). A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology. eLife, 11:e80895.
  • Fay, Rachael; Törő, Imre; Schinke, Anna-Lena; Simic, Branko; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Holland, Jason P (2022). Sortase-Mediated Site-Specific Conjugation and 89Zr-Radiolabeling of Designed Ankyrin Repeat Proteins for PET. Molecular Pharmaceutics, 19(10):3576-3585.
  • Strittmatter, Tobias; Wang, Yidan; Bertschi, Adrian; Scheller, Leo; Freitag, Patrick C; Ray, Preetam Guha; Stuecheli, Pascal; Schaefer, Jonas V; Reinberg, Thomas; Tsakiris, Dimitrios; Plückthun, Andreas; Ye, Haifeng; Fussenegger, Martin (2022). Programmable DARPin-based receptors for the detection of thrombotic markers. Nature Chemical Biology, 18(10):1125-1134.
  • Zhang, Yi; Wang, Yiao; Uslu, Safak; Venkatachalapathy, Sneha; Rashidian, Mohammad; Schaefer, Jonas V; Plückthun, Andreas; Distefano, Mark D (2022). Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy. International Journal of Molecular Sciences, 23(19):11537.
  • Freitag, Patrick C; Brandl, Fabian; Brücher, Dominik; Weiss, Fabian; Dreier, Birgit; Plückthun, Andreas (2022). Modular Adapters Utilizing Binders of Different Molecular Types Expand Cell-Targeting Options for Adenovirus Gene Delivery. Bioconjugate Chemistry, 33(9):1595-1601.
  • Waltenspühl, Yann; Ehrenmann, Janosch; Vacca, Santiago; Thom, Cristian; Medalia, Ohad; Plückthun, Andreas (2022). Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nature Communications, 13:4153.
  • Kirchhammer, Nicole; Trefny, Marcel P; Natoli, Marina; Brücher, Dominik; Smith, Sheena N; Werner, Franziska; Koch, Victoria; Schreiner, David; Bartoszek, Ewelina; Buchi, Mélanie; Schmid, Markus; Breu, Daniel; Hartmann, K Patricia; Zaytseva, Polina; Thommen, Daniela S; Läubli, Heinz; Böttcher, Jan P; Stanczak, Michal A; Kashyap, Abhishek S; Plückthun, Andreas; Zippelius, Alfred (2022). NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity. Science Translational Medicine, 14(653):eabm9043.
  • Kopra, Kari; Valtonen, Salla; Mahran, Randa; Kapp, Jonas N; Hassan, Nazia; Gillette, William; Dennis, Bryce; Li, Lianbo; Westover, Kenneth D; Plückthun, Andreas; Härmä, Harri (2022). Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability. International Journal of Molecular Sciences, 23(13):7095.
  • Guimaraes Koch, Sofia S; Thorpe, Robin; Kawasaki, Nana; Lefranc, Marie-Paule; Malan, Sarel; Martin, Andrew C R; Mignot, Gilles; Plückthun, Andreas; Rizzi, Menico; Shubat, Stephanie; Weisser, Karin; Balocco, Raffaella (2022). International nonproprietary names for monoclonal antibodies: an evolving nomenclature system. mAbs, 14(1):2075078.
  • Wang, Longlong; Moreira, Etori Aguiar; Kempf, Georg; Miyake, Yasuyuki; Oliveira Esteves, Blandina I; Fahmi, Amal; Schaefer, Jonas V; Dreier, Birgit; Yamauchi, Yohei; Alves, Marco P; Plückthun, Andreas; Matthias, Patrick (2022). Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Reports, 39(4):110736.
  • Gisdon, Florian J; Kynast, Josef P; Ayyildiz, Merve; Hine, Anna V; Plückthun, Andreas; Höcker, Birte (2022). Modular peptide binders - development of a predictive technology as alternative for reagent antibodies. Biological Chemistry, 403(5-6):535-543.
  • Schöppe, Jendrik; Ehrenmann, Janosch; Waltenspühl, Yann; Plückthun, Andreas (2022). Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP. Nature Protocols, 17(3):698-726.
  • Qi, Chao; Lavriha, Pia; Mehta, Ved; Khanppnavar, Basavraj; Mohammed, Inayathulla; Li, Yong; Lazaratos, Michalis; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Bondar, Ana-Nicoleta; Dessauer, Carmen W; Korkhov, Volodymyr M (2022). Structural basis of adenylyl cyclase 9 activation. Nature Communications, 13:1045.
  • Deluigi, Mattia; Morstein, Lena; Schuster, Matthias; Klenk, Christoph; Merklinger, Lisa; Cridge, Riley R; de Zhang, Lazarus A; Klipp, Alexander; Vacca, Santiago; Vaid, Tasneem M; Mittl, Peer R E; Egloff, Pascal; Eberle, Stefanie A; Zerbe, Oliver; Chalmers, David K; Scott, Daniel J; Plückthun, Andreas (2022). Crystal structure of the α$_{1B}$-adrenergic receptor reveals molecular determinants of selective ligand recognition. Nature Communications, 13(1):382.
  • Matsuda, Shinya; Schaefer, Jonas V; Mii, Yusuke; Hori, Yutaro; Bieli, Dimitri; Taira, Masanori; Plückthun, Andreas; Affolter, Markus (2022). Author Correction: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nature Communications, 13(1):389.

Pagination