Publications of the Plückthun Group

ZORA Publication List

Publications

• 2024

  • Stark, Y., Menard, F., Jeliazkov, J. R., Ernst, P., Chembath, A., Ashraf, M., Hine, A. V., & Plückthun, A. (2024). Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules Proceedings of the National Academy of Sciences of the United States of America, 121, e2318198121. https://doi.org/10.1073/pnas.2318198121
  • Dederer, V., Sanz Murillo, M., Karasmanis, E. P., Hatch, K. S., Chatterjee, D., Preuss, F., Abdul Azeez, K. R., Nguyen, L. V., Galicia, C., Dreier, B., Plückthun, A., Versees, W., Mathea, S., Leschziner, A. E., Reck-Peterson, S. L., & Knapp, S. (2024). A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2. Journal of Biological Chemistry, 300, 107469. https://doi.org/10.1016/j.jbc.2024.107469
  • Houvast, R. D., Badr, N., March, T., de Muynck, L. D. A. N., Sier, V. Q., Schomann, T., Bhairosingh, S., Baart, V. M., Peeters, J. A. H. M., van Westen, G. J. P., Plückthun, A., Burggraaf, J., Kuppen, P. J. K., Vahrmeijer, A. L., & Sier, C. F. M. (2024). Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer European Journal of Nuclear Medicine and Molecular Imaging, 51, 2179–2192. https://doi.org/10.1007/s00259-023-06407-w
  • Cui, Z., Ayva, C. E., Liew, Y. J., Guo, Z., Mutschler, R., Dreier, B., Fiorito, M. M., Walden, P., Howard, C. B., Ely, F., Plückthun, A., Pretorius, C., Ungerer, J. P., Buckle, A. M., & Alexandrov, K. (2024). mRNA Display Pipeline for Protein Biosensor Construction ACS Sensors, 9, 2846–2857. https://doi.org/10.1021/acssensors.3c02471
  • Ivanova, J. R., Benk, A. S., Schaefer, J. V., Dreier, B., Hermann, L. O., Plückthun, A., Missirlis, D., & Spatz, J. P. (2024). Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells ACS Nano, 18, 8919–8933. https://doi.org/10.1021/acsnano.3c12265
  • Klinnert, S., Schenkel, C. D., Freitag, P. C., Günthard, H. F., Plückthun, A., & Metzner, K. J. (2024). Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery Gene Therapy, 31, 74–84. https://doi.org/10.1038/s41434-023-00413-1
  • Thalmann, L., Martín-González, N., Brücher, D., Plückthun, A., de Pablo, P. J., Suomalainen, M., & Greber, U. (2024). Gutless helper-dependent and first generation HAdV5 vectors have similar mechanical properties and common transduction mechanisms Human Gene Therapy, 35, 163–176. https://doi.org/10.1089/hum.2023.221
  • Abdul-Ridha, A., de Zhang, L. A., Betrie, A. H., Deluigi, M., Vaid, T. M., Whitehead, A., Zhang, Y., Davis, B., Harris, R., Simmonite, H., Hubbard, R. E., Gooley, P. R., Plückthun, A., Bathgate, R. A. D., Chalmers, D. K., & Scott, D. J. (2024). Identification of a Novel Subtype-Selective α$_{1B}$-Adrenoceptor Antagonist ACS Chemical Neuroscience, 15, 671–684. https://doi.org/10.1021/acschemneuro.3c00767

• 2023

  • Leka, O., Wu, Y., Zanetti, G., Furler, S., Reinberg, T., Marinho, J., Schaefer, J. V., Plückthun, A., Li, X., Pirazzini, M., & Kammerer, R. A. (2023). A DARPin promotes faster onset of botulinum neurotoxin A1 action Nature Communications, 14, 8317. https://doi.org/10.1038/s41467-023-44102-4
  • Cucuzza, S., Sitnik, M., Jurt, S., Michel, E., Dai, W., Müntener, T., Ernst, P., Häussinger, D., Plückthun, A., & Zerbe, O. (2023). Unexpected dynamics in femtomolar complexes of binding proteins with peptides Nature Communications, 14, 7823. https://doi.org/10.1038/s41467-023-43596-2
  • Baumann, C., Chiang, W., Valsecchi, R., Jurt, S., Deluigi, M., Schuster, M., Rosengren, K. J., Plückthun, A., & Zerbe, O. (2023). Side‐chain dynamics of the α$_{1B}$ ‐adrenergic receptor determined by NMR via methyl relaxation Protein Science, 32, e4801. https://doi.org/10.1002/pro.4801
  • Strubel, A., Münick, P., Hartmann, O., Chaikuad, A., Dreier, B., Schaefer, J. V., Gebel, J., Osterburg, C., Tuppi, M., Schäfer, B., Buck, V., Rosenfeldt, M., Knapp, S., Plückthun, A., Diefenbacher, M. E., & Dötsch, V. (2023). DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma Cell Death and Disease, 14, 674. https://doi.org/10.1038/s41419-023-06213-0
  • Hartmann, K. P., van Gogh, M., Freitag, P. C., Kast, F., Nagy-Davidescu, G., Borsig, L., & Plückthun, A. (2023). FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment Molecular Therapy, 31, 2914–2928. https://doi.org/10.1016/j.ymthe.2023.08.018
  • Maliqi, L., Friedrich, N., Glögl, M., Schmutz, S., Schmidt, D., Rusert, P., Schanz, M., Zaheri, M., Pasin, C., Niklaus, C., Foulkes, C., Reinberg, T., Dreier, B., Abela, I., Peterhoff, D., Hauser, A., Kouyos, R. D., Günthard, H. F., van Gils, M. J., … Trkola, A. (2023). Assessing immunogenicity barriers of the HIV-1 envelope trimer Npj Vaccines, 8, 148. https://doi.org/10.1038/s41541-023-00746-3
  • Glögl, M., Friedrich, N., Cerutti, G., Lemmin, T., Kwon, Y. D., Gorman, J., Maliqi, L., Mittl, P. R. E., Hesselman, M. C., Schmidt, D., Weber, J., Foulkes, C., Dingens, A. S., Bylund, T., Olia, A. S., Verardi, R., Reinberg, T., Baumann, N. S., Rusert, P., … Trkola, A. (2023). Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization Nature Structural & Molecular Biology, 30, 1323–1336. https://doi.org/10.1038/s41594-023-01062-z
  • Shi, J., Hauschulte, K., Mikicic, I., Maharjan, S., Arz, V., Strauch, T., Heidelberger, J. B., Schaefer, J. V., Dreier, B., Plückthun, A., Beli, P., Ulrich, H. D., & Wollscheid, H.-P. (2023). Nuclear myosin VI maintains replication fork stability Nature Communications, 14, 3787. https://doi.org/10.1038/s41467-023-39517-y
  • Freitag, P. C., Kaulfuss, M., Flühler, L., Mietz, J., Weiss, F., Brücher, D., Kolibius, J., Hartmann, K. P., Smith, S. N., Münz, C., Chijioke, O., & Plückthun, A. (2023). Targeted adenovirus-mediated transduction of human T cells in vitro and in vivo Molecular Therapy - Methods & Clinical Development, 29, 120–132. https://doi.org/10.1016/j.omtm.2023.02.012
  • Becker, L., & Plückthun, A. (2023). DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin Scientific Reports, 13, 8048. https://doi.org/10.1038/s41598-023-34647-1
  • Gut, M., Dreier, B., Furler, S., Sobek, J., Plückthun, A., & Holland, J. P. (2023). Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo RSC Chemical Biology, 4, 494–505. https://doi.org/10.1039/d3cb00010a
  • Blanc, M., Lettl, C., Guérin, J., Vieille, A., Furler, S., Briand-Schumacher, S., Dreier, B., Bergé, C., Plückthun, A., Vadon-Le Goff, S., Fronzes, R., Rousselle, P., Fischer, W., & Terradot, L. (2023). Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system PLoS Pathogens, 19, e1011368. https://doi.org/10.1371/journal.ppat.1011368

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