Publications of the Plückthun Group

ZORA Publication List

Publications

• 2019

  • Deprey, K., Becker, L., Kritzer, J., & Plückthun, A. (2019). Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization Bioconjugate Chemistry, 30, 1006–1027. https://doi.org/10.1021/acs.bioconjchem.9b00112
  • Heine, P., Witt, G., Gilardi, A., Gribbon, P., Kummer, L., & Plückthun, A. (2019). High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor SLAS Discovery, 2472555219837344. https://doi.org/10.1177/2472555219837344
  • Michel, E., Plückthun, A., & Zerbe, O. (2019). Peptide binding affinity redistributes preassembled repeat protein fragments Biological Chemistry, 400, 395–404. https://doi.org/10.1515/hsz-2018-0355
  • Tomatis, P. E., Schütz, M., Umudumov, E., & Plückthun, A. (2019). Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli Scientific Reports, 9, 2483. https://doi.org/10.1038/s41598-019-39492-9
  • Schwill, M., Tamaskovic, R., Gajadhar, A. S., Kast, F., White, F. M., & Plückthun, A. (2019). Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer Science Signaling, 12, 1–23. https://doi.org/10.1126/scisignal.aau2875
  • Schöppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schütz, M., Doré, A. S., & Plückthun, A. (2019). Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists Nature Communications, 10, 17. https://doi.org/10.1038/s41467-018-07939-8
  • Kumar, A., & Plückthun, A. (2019). In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex PLoS ONE, 14, e0210131. https://doi.org/10.1371/journal.pone.0210131
  • Stüber, J. C., & Plückthun, A. (2019). Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems PLoS ONE, 14, e0226579. https://doi.org/10.1371/journal.pone.0226579

• 2018

  • Vigano, M. A., Bieli, D., Schaefer, J. V., Jakob, R. P., Matsuda, S., Maier, T., Plückthun, A., & Affolter, M. (2018). Correction: DARPins recognizing mTFP1 as novel reagents for and protein manipulations (doi:10.1242/bio.036749) Biology Open, 7, 1. https://doi.org/10.1242/bio.040832
  • Ehrenmann, J., Schöppe, J., Klenk, C., Rappas, M., Kummer, L., Doré, A. S., & Plückthun, A. (2018). High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist Nature Structural & Molecular Biology, 25, 1086–1092. https://doi.org/10.1038/s41594-018-0151-4
  • Vigano, M. A., Bieli, D., Schaefer, J. V., Jakob, R. P., Matsuda, S., Maier, T., Plückthun, A., & Affolter, M. (2018). DARPins recognize mTFP1 as novel reagents for and protein manipulations Biology Open, 7, 036749. https://doi.org/10.1242/bio.036749
  • ElGamacy, M., Coles, M., Ernst, P., Zhu, H., Hartmann, M. D., Plückthun, A., & Lupas, A. N. (2018). An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture ACS Synthetic Biology, 7, 2226–2235. https://doi.org/10.1021/acssynbio.8b00224
  • Hartmann, J., Münch, R. C., Freiling, R.-T., Schneider, I. C., Dreier, B., Samukange, W., Koch, J., Seeger, M. A., Plückthun, A., & Buchholz, C. J. (2018). A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors Molecular Therapy - Methods & Clinical Development, 10, 128–143. https://doi.org/10.1016/j.omtm.2018.07.001
  • Mikula, K. M., Krumwiede, L., Plückthun, A., & Iwaï, H. (2018). Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation Journal of Biomolecular NMR, 71, 225–235. https://doi.org/10.1007/s10858-018-0175-4
  • Wu, Y., Honegger, A., Batyuk, A., Mittl, P. R. E., & Plückthun, A. (2018). Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions Journal of Molecular Biology, 430, 2128–2138. https://doi.org/10.1016/j.jmb.2017.10.032
  • Yen, H.-Y., Hoi, K. K., Liko, I., Hedger, G., Horrell, M. R., Song, W., Wu, D., Heine, P., Warne, T., Lee, Y., Carpenter, B., Plückthun, A., Tate, C. G., Sansom, M. S. P., & Robinson, C. V. (2018). PtdIns(4,5)P stabilizes active states of GPCRs and enhances selectivity of G-protein coupling Nature, 559, 423–427. https://doi.org/10.1038/s41586-018-0325-6
  • Radom, F., Plückthun, A., & Paci, E. (2018). Assessment of ab initio models of protein complexes by molecular dynamics PLoS Computational Biology, 14, e1006182. https://doi.org/10.1371/journal.pcbi.1006182
  • Schaefer, J. V., Sedlák, E., Kast, F., Nemergut, M., & Plückthun, A. (2018). Modification of the kinetic stability of immunoglobulin G by solvent additives MAbs, 10, 607–623. https://doi.org/10.1080/19420862.2018.1450126
  • Yong, K. J., Vaid, T. M., Shilling, P. J., Wu, F.-J., Williams, L. M., Deluigi, M., Plückthun, A., Bathgate, R. A. D., Gooley, P. R., & Scott, D. J. (2018). Determinants of Ligand Subtype-Selectivity at α-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR ACS Chemical Biology, 13, 1090–1102. https://doi.org/10.1021/acschembio.8b00191
  • Stichling, N., Suomalainen, M., Flatt, J. W., Schmid, M., Pacesa, M., Hemmi, S., Jungraithmayr, W., Maler, M. D., Freudenberg, M. A., Plückthun, A., May, T., Köster, M., Fejer, G., & Greber, U. F. (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor PLoS Pathogens, 14, e1006914. https://doi.org/10.1371/journal.ppat.1006914

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