Publications 2024

by date of publication in PubMed, most recent at the top:

2024

Weibel, N., Curcio, M., Schreiber, A., Arriaga, G., Mausy, M., Mehdy, J., Brüllmann, L., Meyer, A., Roth, L., Flury, T., Pecina, V., Starlinger, K., Dernič, J., Jungfer, K., Ackle, F., Earp, J., Hausmann, M., Jinek, M., Rogler, G. & Antunes Westmann, C. Engineering a Novel Probiotic Toolkit in Escherichia coli Nissle 1917 for Sensing and Mitigating Gut Inflammatory Diseases. ACS Synth Biol [Epub ahead of print] (2024). PMID: 39115381.

Freitag, PC., Kolibius, J., Wieboldt, R., Weber, R., Hartmann, KP., van Gogh, M., Brücher, D., Läubli, H. & Plückthun, A. DARPin-fused T cell engager for adenovirus-mediated cancer therapy. Mol Ther Oncol 32, 200821 (2024). PMID: 39021370.

Nüesch, MF., Pietrek, L., Holmstrom, ED., Nettels, D., von Roten, V., Kronenberg-Tenga, R., Medalia, O., Hummer, G. & Schuler, B. Nanosecond chain dynamics of single-stranded nucleic acids. Nat Commun 15, 6010 (2024). PMID: 39019880.

Reginato, G., Dello Stritto, MR., Wang, Y., Hao, J., Pavani, R., Schmitz, M., Halder, S., Morin, V., Cannavo, E., Ceppi, I., Braunshier, S., Acharya, A., Ropars, V., Charbonnier, JB., Jinek, M., Nussenzweig, A., Ha, T. & Cejka, P. HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing. Nat Commun 15, 5789 (2024). PMID: 38987539.

Siow, KM., Güngör, M., Wrona, D., Raimondi, F., Pastukhov, O., Tsapogas, P., Menzi, T., Schmitz, M., Kulcsár, PI., Schwank, G., Schulz, A., Jinek, M., Modlich, U., Siler, U. & Reichenbach, J. Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47 ^phox-deficient chronic granulomatous disease. Mol Ther Nucleic Acids 35, 102229 (2024). PMID: 38952440.

Bastiaanssen, C., Bobadilla Ugarte, P., Kim, K., Finocchio, G., Feng, Y., Anzelon, TA., Köstlbacher, S., Tamarit, D., Ettema, TJG., Jinek, M., MacRae, IJ., Joo, C., Swarts, DC. & Wu, F. RNA-guided RNA silencing by an Asgard archaeal Argonaute. Nat Commun 15, 5499 (2024). PMID: 38951509.

Stark, Y., Menard, F., Jeliazkov, JR., Ernst, P., Chembath, A., Ashraf, M., Hine, AV. & Plückthun, A. Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules. Proc Natl Acad Sci U S A 121, e2318198121 (2024). PMID: 38917007.

Zhou, J., Assenza, S., Tatli, M., Tian, J., Ilie, IM., Starostin, EL., Caflisch, A., Knowles, TPJ., Dietler, G., Ruggeri, FS., Stahlberg, H., Sekatskii, SK. & Mezzenga, R. Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs. Adv Sci (Weinh) [Epub ahead of print] (2024). PMID: 38899849.

Drożdżyk, K., Peter, M. & Dutzler, R. Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs. Elife 13, (2024). PMID: 38896440.

Dederer, V., Sanz Murillo, M., Karasmanis, EP., Hatch, KS., Chatterjee, D., Preuss, F., Abdul Azeez, KR., Nguyen, LV., Galicia, C., Dreier, B., Plückthun, A., Versees, W., Mathea, S., Leschziner, AE., Reck-Peterson, SL. & Knapp, S. A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. J Biol Chem 300, 107469 (2024). PMID: 38876305.

Loeff, L., Adams, DW., Chanez, C., Stutzmann, S., Righi, L., Blokesch, M. & Jinek, M. Molecular mechanism of plasmid elimination by the DdmDE defense system. Science 385, 188-194 (2024). PMID: 38870273.

Kechagia, Z., Eibauer, M. & Medalia, O. Structural determinants of intermediate filament mechanics. Curr Opin Cell Biol 89, 102375 (2024). PMID: 38850681.

Cui, Z., Ayva, CE., Liew, YJ., Guo, Z., Mutschler, R., Dreier, B., Fiorito, MM., Walden, P., Howard, CB., Ely, F., Plückthun, A., Pretorius, C., Ungerer, JP., Buckle, AM. & Alexandrov, K. mRNA Display Pipeline for Protein Biosensor Construction. ACS Sens 9, 2846-2857 (2024). PMID: 38807313.

Zálešák, F., Nai, F., Herok, M., Bochenkova, E., Bedi, RK., Li, Y., Errani, F. & Caflisch, A. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J Med Chem 67, 9516-9535 (2024). PMID: 38787793.

Auger, SA., Venkatachalapathy, S., Suazo, KFG., Wang, Y., Sarkis, AW., Bernhagen, K., Justyna, K., Schaefer, JV., Wollack, JW., Plückthun, A., Li, L. & Distefano, MD. Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjug Chem [Epub ahead of print] (2024). PMID: 38654427.

Nai, F., Flores Espinoza, MP., Invernizzi, A., Vargas-Rosales, PA., Bobileva, O., Herok, M. & Caflisch, A. Small-Molecule Inhibitors of the m7G-RNA Writer METTL1. ACS Bio Med Chem Au 4, 100-110 (2024). PMID: 38645929.

Eibauer, M., Weber, MS., Kronenberg-Tenga, R., Beales, CT., Boujemaa-Paterski, R., Turgay, Y., Sivagurunathan, S., Kraxner, J., Köster, S., Goldman, RD. & Medalia, O. Vimentin filaments integrate low-complexity domains in a complex helical structure. Nat Struct Mol Biol [Epub ahead of print] (2024). PMID: 38632361.

Ivanova, JR., Benk, AS., Schaefer, JV., Dreier, B., Hermann, LO., Plückthun, A., Missirlis, D. & Spatz, JP. Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS Nano 18, 8919-8933 (2024). PMID: 38489155.

Corbeski, I., Vargas-Rosales, PA., Bedi, RK., Deng, J., Coelho, D., Braud, E., Iannazzo, L., Li, Y., Huang, D., Ethève-Quelquejeu, M., Cui, Q. & Caflisch, A. The catalytic mechanism of the RNA methyltransferase METTL3. Elife 12, (2024). PMID: 38470714.

Weber, Y., Böck, D., Ivașcu, A., Mathis, N., Rothgangl, T., Ioannidi, EI., Blaudt, AC., Tidecks, L., Vadovics, M., Muramatsu, H., Reichmuth, A., Marquart, KF., Kissling, L., Pardi, N., Jinek, M. & Schwank, G. Enhancing prime editor activity by directed protein evolution in yeast. Nat Commun 15, 2092 (2024). PMID: 38453904.

Pacesa, M., Pelea, O. & Jinek, M. Past, present, and future of CRISPR genome editing technologies. Cell 187, 1076-1100 (2024). PMID: 38428389.

Errani, F., Invernizzi, A., Herok, M., Bochenkova, E., Stamm, F., Corbeski, I., Romanucci, V., Di Fabio, G., Zálešák, F. & Caflisch, A. Proteolysis Targeting Chimera Degraders of the METTL3-14 m6A-RNA Methyltransferase. JACS Au 4, 713-729 (2024). PMID: 38425900.

Thalmann, L., Martin-Gonzalez, N., Brücher, D., Plückthun, A., de Pablo, PJ., Suomalainen, M. & Greber, UF. Gutless Helper-Dependent and First-Generation HAdV5 Vectors Have Similar Mechanical Properties and Common Transduction Mechanisms. Hum Gene Ther 35, 163-176 (2024). PMID: 38386500.

Saha, A., Ahsan, M., Arantes, PR., Schmitz, M., Chanez, C., Jinek, M. & Palermo, G. An alpha-helical lid guides the target DNA toward catalysis in CRISPR-Cas12a. Nat Commun 15, 1473 (2024). PMID: 38368461.

Grabenhorst, L., Sturzenegger, F., Hasler, M., Schuler, B. & Tinnefeld, P. Single-Molecule FRET at 10 MHz Count Rates. J Am Chem Soc 146, 3539-3544 (2024). PMID: 38266173.

Tinzl, M., Diedrich, JV., Mittl, PRE., Clémancey, M., Reiher, M., Proppe, J., Latour, JM. & Hilvert, D. Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate. J Am Chem Soc 146, 1957-1966 (2024). PMID: 38264790.

Abdul-Ridha, A., de Zhang, LA., Betrie, AH., Deluigi, M., Vaid, TM., Whitehead, A., Zhang, Y., Davis, B., Harris, R., Simmonite, H., Hubbard, RE., Gooley, PR., Plückthun, A., Bathgate, RAD., Chalmers, DK. & Scott, DJ. Identification of a Novel Subtype-Selective α1B  Adrenoceptor Antagonist. ACS Chem Neurosci  15, 671-684 (2024). PMID: 38238043.

Finocchio, G., Koopal, B., Potocnik, A., Heijstek, C., Westphal, AH., Jinek, M. & Swarts, DC. Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA. Nucleic Acids Res,  52, 2012-2029 (2024). PMID: 38224450.

Jungfer, K., Sigg, A. & Jinek, M. Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res 52, 462-473 (2024). PMID: 38033326.

Klinnert, S., Schenkel, CD., Freitag, PC., Günthard, HF., Plückthun, A. & Metzner, KJ. Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery. Gene Ther 31, 74-84 (2024). PMID: 37558852.

Schmidheini, L., Mathis, N., Marquart, KF., Rothgangl, T., Kissling, L., Böck, D., Chanez, C., Wang, JP., Jinek, M. & Schwank, G. Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility. Nat Chem Biol 20, 333-343 (2024). PMID: 37735239.