Engineering and Directed Evolution of Proteins


We study the creation of new proteins and protein variants.

The purpose of this work is to use such engineered proteins to enable research and applications which have been very difficult or even impossible to carry out/develop so far. Examples of our endeavors are the creation of new engineered binding proteins to inhibit other proteins or to kill tumor cells, or the stabilization of proteins so that they can be studied structurally and biophysically.

Our main areas of interest are novel scaffolds for selective binding, synthetic antibodies and G-protein-coupled receptors (integral membrane proteins). Because of the complexity of the task, this research requires a highly interdisciplinary approach, combining detailed biophysical studies, computer modeling and advanced molecular biology, especially directed evolution.